G
Gong Chen
Researcher at Nankai University
Publications - 177
Citations - 8709
Gong Chen is an academic researcher from Nankai University. The author has contributed to research in topics: Catalysis & Alkyl. The author has an hindex of 45, co-authored 162 publications receiving 6921 citations. Previous affiliations of Gong Chen include Kunming Institute of Zoology & Memorial Sloan Kettering Cancer Center.
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Coordination of PAD4 and HDAC2 in the regulation of p53-target gene expression.
TL;DR: The results unveil an important crosstalk between histone deacetylation and citrullination, suggesting that a combination of PAD4 and HDAC2 inhibitors as a potential strategy for cancer treatment.
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Iridium-Catalyzed Enantioselective C(sp 3 )-H Amidation Controlled by Attractive Noncovalent Interactions
TL;DR: The development of a highly enantioselective Ir(III)-catalyzed intramolecular C(sp3)-H amidation reaction of dioxazolone substrates for synthesis of optically enriched γ-lactams using a newly designed α-amino-acid-based chiral ligand.
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An Enantioselective Bidentate Auxiliary Directed Palladium-Catalyzed Benzylic C−H Arylation of Amines Using a BINOL Phosphate Ligand
TL;DR: A new enantioselective palladium(II)-catalyzed benzylic C-H arylation reaction of amines is enabled by the bidentate picolinamide (PA) directing group, and provides the first example of enantiOSElectivebenzylic γ-C- H arylations of alkyl amines.
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Reactivity of functional groups on the protein surface: development of epoxide probes for protein labeling.
Gong Chen,Alexander Heim,Doris Riether,Dominic J. Yee,Yelena Milgrom,Mary Ann Gawinowicz,Dalibor Sames +6 more
TL;DR: Systematic screening revealed that an epoxide functionality possesses the special combination of stability and reactivity which renders it stable toward proteins in solution but reactive on the protein surface outside the active site (proximity-induced reactivity).
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Palladium-catalyzed trifluoroacetate-promoted mono-arylation of the β-methyl group of alanine at room temperature: synthesis of β-arylated α-amino acids through sequential C–H functionalization
TL;DR: For the first time, a broad range of easily accessible aryl iodides can be installed onto the β-methyl group of AQ-coupled phthaloyl alanine mono-selectively, providing both natural and unnatural aromatic α-amino acids.