Gong Chen

TL;DR: In this paper, a pan-PAD inhibitor YW3-56 activated p53 target genes to inhibit cancer growth, but the p53-independent anticancer activity and molecular mechanisms were largely elusive.

TL;DR: The Ala(1)-Gly(28) glycopeptide fragment (28) of EPO was prepared by chemical synthesis as a single glycoform that contains both the requisite N-linked dodecasaccharide and a C-terminal (alpha)thioester handle, the latter feature permitting direct coupling with a glycopePTide fragment bearing N- terminal Cys(29) without further functionalization.

TL;DR: In this article, a nitrene-mediated intermolecular N-N coupling of dioxazolones and arylamines under iridium or iron catalysis was reported.

TL;DR: The growing importance of peptides and proteins in therapeutic and biomedical applications has provided immense motivation toward the development of new ways to construct and transform peptide mole...

TL;DR: The first total synthesis of mannopeptimycin α and β with fully elaborated N- and O-linked sugars is reported, and a gold-catalyzed N-glycosylation of a D- βhEnd substrate with a mannosyl ortho-alkynylbenzoate donor enabled the synthesis of the most challenging N-Man-D-βhEnd unit with excellent efficiency and stereoselectivity.