G
Gopinath Prakasam
Researcher at Jawaharlal Nehru University
Publications - 9
Citations - 624
Gopinath Prakasam is an academic researcher from Jawaharlal Nehru University. The author has contributed to research in topics: PKM2 & Cancer. The author has an hindex of 6, co-authored 7 publications receiving 357 citations. Previous affiliations of Gopinath Prakasam include University of Texas Southwestern Medical Center.
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MicroRNA in lung cancer: role, mechanisms, pathways and therapeutic relevance
TL;DR: The role of miRNA in lung cancer has been dissected and the associated mechanisms and pathways are discussed in this review.
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Curcumin decreases Warburg effect in cancer cells by down-regulating pyruvate kinase M2 via mTOR-HIF1α inhibition.
Farid Ahmad Siddiqui,Gopinath Prakasam,Shilpi Chattopadhyay,Asad Ur Rehman,Rayees Ahmad Padder,Mohammad Afaque Ansari,Rasha Irshad,Kailash Chandra Mangalhara,Rameshwar N. K. Bamezai,Mohammad Husain,Syed Mansoor Ali,Mohammad Askandar Iqbal +11 more
TL;DR: It is shown that curcumin inhibits glucose uptake and lactate production (Warburg effect) in a variety of cancer cell lines by down-regulating PKM2 expression, via inhibition of mTOR-HIF1α axis, and PKM 2 over-expression abrogated the effects ofCurcumin, demonstrating that inhibition of Warburg effect by curcuming is PKM1-mediated.
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Posttranslational Modifications of Pyruvate Kinase M2: Tweaks that Benefit Cancer
TL;DR: A large body of data have shown that several distinct posttranslation modifications (PTMs) regulate PKM2 in a way that benefits cancer growth, e.g., formation ofPKM2 dimers.
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DNA Methyltransferase1 (DNMT1) Isoform3 methylates mitochondrial genome and modulates its biology.
TL;DR: This study reveals how DNMT1-isoform3, instead of isoform1, is responsible for mtDNA methylation, influencing its biology and down-regulated, resulting in hypomethylation of mitochondrial genome.
Journal ArticleDOI
Pyruvate kinase M knockdown–induced signaling via AMP-activated protein kinase promotes mitochondrial biogenesis, autophagy, and cancer cell survival
Gopinath Prakasam,Rajnish Kumar Singh,Mohammad Askandar Iqbal,Sunil Kumar Saini,Ashu Bhan Tiku,Rameshwar N. K. Bamezai +5 more
TL;DR: It is shown that knockdown of either PKM1 or PKM2 differentially affects net PK activity, viability, and cellular ATP levels of the lung carcinoma cell lines H1299 and A549, and an alternative therapeutic strategy of silencing either of the PKM isoforms along with AMPK in tumors is proposed.