Asad Ur Rehman

TL;DR: It is shown that curcumin inhibits glucose uptake and lactate production (Warburg effect) in a variety of cancer cell lines by down-regulating PKM2 expression, via inhibition of mTOR-HIF1α axis, and PKM 2 over-expression abrogated the effects ofCurcumin, demonstrating that inhibition of Warburg effect by curcuming is PKM1-mediated.

TL;DR: The results highlight the importance of EGFR‐MYC‐TXNIP axis in regulating TNBC metabolism, demonstrate the anti‐TNBC activity of silibinin, and argue in favor of targeting metabolic vulnerabilities of TNBC, at least in combination with mainstay chemotherapeutic drugs, to effectively treat TNBC patients.

TL;DR: The expression of YAP was found to be downregulated in response to aberrant promoter methylation, consistent with previous studies suggesting it to have a tumor suppressive role in breast cancer.

TL;DR: In this article, the authors performed pathway-based analysis and identified outstanding roles of CBX2 and CBX7 in positive and negative regulation of glucose metabolism, respectively, using transcriptomic and metabolomic data from breast cancer patients.

TL;DR: The data presented in this study provide new insights into the biology of RUNX3 and highlights the need to revisit the current understanding of the role of RunX3 in cancer.