G
Gordon R. Bernard
Researcher at Vanderbilt University Medical Center
Publications - 366
Citations - 82519
Gordon R. Bernard is an academic researcher from Vanderbilt University Medical Center. The author has contributed to research in topics: Lung injury & Sepsis. The author has an hindex of 103, co-authored 346 publications receiving 70417 citations. Previous affiliations of Gordon R. Bernard include Vanderbilt University & Louisiana State University.
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Journal ArticleDOI
Top-down proteomic analysis by MALDI-TOF profiling: Concentration-independent biomarkers.
Gary L. Nelsestuen,Stephen B. Harvey,Yan Zhang,Raj S. Kasthuri,Alan R. Sinaiko,E. Wesley Ely,Gordon R. Bernard,Monika Homoncik,Bernd Jilma +8 more
TL;DR: This review focuses on intact protein isoform ratios that present a biomarker without change in the total concentration of the protein, which will seldom be detected by peptide level analysis or by most antibody‐based assays.
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Randomised controlled pragmatic clinical trial evaluating the effectiveness of a discharge follow-up phone call on 30-day hospital readmissions: balancing pragmatic and explanatory design considerations
Maame Yaa A. B. Yiadom,Henry J. Domenico,Daniel W. Byrne,Michele Hasselblad,Cheryl L Gatto,Sunil Kripalani,Neesha N. Choma,Sarah Tucker,Li Wang,Monisha C Bhatia,Johnston Morrison,Frank E. Harrell,Tina V. Hartert,Gordon R. Bernard +13 more
TL;DR: This is a single-centre pragmatic randomised and controlled clinical trial examining the effectiveness of a discharge follow-up phone call to reduce 30-day inpatient readmissions in a hospital-wide evidence-based practice directly affecting patients.
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Motivation for Launching a Cancer Metastasis Inhibition (CMI) Program
Jill M. Pulley,Rebecca N Jerome,Martin L. Ogletree,Gordon R. Bernard,Robert R. Lavieri,Nicole M. Zaleski,Charles C. Hong,Jana K. Shirey-Rice,Carlos L. Arteaga,Ingrid A. Mayer,Kenneth J. Holroyd,Rebecca S. Cook +11 more
TL;DR: Before real progress can be made toward clinical targeting of the metastatic process, foundational work is needed to define informative measures of critical elements such as circulating tumor cells and tumor DNA, and circulatory vs. lymphatic spread.
Journal ArticleDOI
Mechanisms of late hemodynamic and airway dynamic responses to endotoxin in awake sheep.
Patrick Wright,Gordon R. Bernard +1 more
TL;DR: It is concluded that endotoxemia causes prolonged bronchoconstriction and pulmonary hypertension in sheep, which is largely mediated by constrictor prostanoids rather than by cholinergic mechanisms and is reversible with ibuprofen given 2.5 h after endotoxin.
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Vancomycin entry into lung lymph in sheep.
TL;DR: After a minor delay in transit from blood to lymph, vancomycin was completely distributed to pulmonary lymph with a ratio offree drug in lymph to free drug in plasma of 0.9, suggesting that vancomYcin is an excellent choice for treating pulmonary infections by susceptible organisms.