Gordon R. Bernard

TL;DR: Clinical studies in ARDS, as well as sepsis, the leading cause of AR DS, have increased in number, size, and quality over this same period, and each has laid the groundwork for more efficient and more elegant studies of the problem.

TL;DR: These results provide reasons for concern for a harmful effect of MPS on mortality later in the course of ARDS, and were reported by us as significant for prediction of mortality in ARDS/acute lung injury.

TL;DR: It is concluded that perilla ketone causes increased lung microvascular permeability pulmonary edema without acute changes in pulmonary hemodynamics and this model permits study of the pathophysiologic aspects of increased lungmicrov vascular permeability without the concomitant functional alterations that complicate most other experimental models of diffuse lung injury.

TL;DR: In mechanically ventilated patients with severe traumatic injuries, hyperoxia in the first 24 hours of admission was not associated with increased risk of death or worsened neurological outcomes in a setting without brain tissue oxygenation monitoring.

TL;DR: The evolution of sepsis therapy is examined and theorizes about why so many well-reasoned therapies have not worked in human trials and trial designs that might lead to successful treatments for sepsi are examined.