G
Gordon R. Bernard
Researcher at Vanderbilt University Medical Center
Publications - 366
Citations - 82519
Gordon R. Bernard is an academic researcher from Vanderbilt University Medical Center. The author has contributed to research in topics: Lung injury & Sepsis. The author has an hindex of 103, co-authored 346 publications receiving 70417 citations. Previous affiliations of Gordon R. Bernard include Vanderbilt University & Louisiana State University.
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Journal ArticleDOI
Albumin influences total plasma antioxidant capacity favorably in patients with acute lung injury.
Gregory J. Quinlan,Sharon Mumby,Greg S. Martin,Gordon R. Bernard,John M.C. Gutteridge,Timothy W. Evans +5 more
TL;DR: In patients with acute lung injury, albumin administration favorably influences plasma thiol-dependent antioxidant status as well as levels of protein oxidative damage.
Journal ArticleDOI
Acute respiratory distress syndrome: a historical perspective.
TL;DR: The rich combination of new trial strategies, potential treatments, experienced investigators, and increasingly standardized routine care set the stage for rapid advances to be made in the short- and long-term outcomes of this devastating syndrome.
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Systemic Host Responses in Severe Sepsis Analyzed by Causative Microorganism and Treatment Effects of Drotrecogin Alfa (Activated)
Steven M. Opal,Gary Garber,Steven P. LaRosa,Dennis G. Maki,Ross Freebairn,Gary T. Kinasewitz,Jean-François Dhainaut,S. Betty Yan,Mark D. Williams,Delores E. Graham,David R. Nelson,Howard Levy,Gordon R. Bernard +12 more
TL;DR: Results demonstrate that DrotAA, administered as an adjunct to standard anti-infective therapy, can improve the rate of survival for patients who develop severe sepsis regardless of causative microorganism.
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Hypoproteinemia predicts acute respiratory distress syndrome development, weight gain, and death in patients with sepsis.
Robert J. Mangialardi,Greg S. Martin,Gordon R. Bernard,Arthur P. Wheeler,Brian W. Christman,William D. Dupont,Stanley B. Higgins,Bridget B. Swindell +7 more
TL;DR: Hypoproteinemia is significantly correlated with fluid retention and weight gain, development of ARDS and poor respiratory outcome, and mortality in patients with sepsis and prospective, randomized trials of serum protein manipulation are needed.
Journal ArticleDOI
Changing pattern of organ dysfunction in early human sepsis is related to mortality.
James A. Russell,Joel Singer,Gordon R. Bernard,Arthur P. Wheeler,William Fulkerson,Leonard D. Hudson,Roland M. H. Schein,Warren R. Summer,Patrick Wright,Keith R. Walley +9 more
TL;DR: Increased mortality rate in sepsis syndrome is associated with a pattern characterized by failure of nonpulmonary organ systems and, in particular, worsening neurologic, coagulation, and renal dysfunction over the first 3 days.