G
Görkem Garipler
Researcher at New York University
Publications - 10
Citations - 275
Görkem Garipler is an academic researcher from New York University. The author has contributed to research in topics: Mitochondrial DNA & Mitochondrion. The author has an hindex of 7, co-authored 10 publications receiving 208 citations. Previous affiliations of Görkem Garipler include Koç University & University of Tampere.
Papers
More filters
Journal ArticleDOI
A multi-step transcriptional and chromatin state cascade underlies motor neuron programming from embryonic stem cells
Silvia Velasco,Mahmoud M. Ibrahim,Mahmoud M. Ibrahim,Akshay Kakumanu,Görkem Garipler,Begüm Aydin,Mohamed Al-Sayegh,Mohamed Al-Sayegh,Antje Hirsekorn,Farah Abdul-Rahman,Rahul Satija,Uwe Ohler,Uwe Ohler,Shaun Mahony,Esteban O. Mazzoni +14 more
TL;DR: This analysis reveals a highly dynamic process in which Ngn2 and the Isl1/Lhx3 pair initially engage distinct regulatory regions, and motor neuron programming is the product of two initially independent transcriptional modules that converge with a feedforward transcriptional logic.
Journal ArticleDOI
Proneural factors Ascl1 and Neurog2 contribute to neuronal subtype identities by establishing distinct chromatin landscapes
Begüm Aydin,Akshay Kakumanu,Mary Rossillo,Mireia Moreno-Estellés,Görkem Garipler,Niels Ringstad,Nuria Flames,Shaun Mahony,Esteban O. Mazzoni +8 more
TL;DR: This study provides a mechanistic understanding of how transcription factors constrain terminal cell fates, and it delineates the importance of choosing the right proneural factor in neuronal reprogramming strategies.
Journal ArticleDOI
Mitochondrial Dysfunction Plus High-Sugar Diet Provokes a Metabolic Crisis That Inhibits Growth.
Esko Kemppainen,Jack M. George,Görkem Garipler,Görkem Garipler,Tea Tuomela,Essi Kiviranta,Tomoyoshi Soga,Cory D. Dunn,Howard T. Jacobs,Howard T. Jacobs +9 more
TL;DR: The Drosophila mutant tko25t exhibits a deficiency of mitochondrial protein synthesis, leading to a global insufficiency of respiration and oxidative phosphorylation, which entrains an organismal phenotype of developmental delay and sensitivity to seizures induced by mechanical stress.
Journal ArticleDOI
Deletion of conserved protein phosphatases reverses defects associated with mitochondrial DNA damage in Saccharomyces cerevisiae
TL;DR: Deletion of protein phosphatases 2A or PP6 protects cells from the reduced proliferation, mitochondrial protein import defects, lower mitochondrial electrochemical potential, and nuclear transcriptional response associated with mtDNA damage, suggesting a potential therapeutic approach for mitochondrial disease.
Journal ArticleDOI
Defects Associated with Mitochondrial DNA Damage Can Be Mitigated by Increased Vacuolar pH in Saccharomyces cerevisiae
Görkem Garipler,Cory D. Dunn +1 more
TL;DR: It is found that disrupting vacuolar biogenesis permitted survival of a sensitized yeast background after mitochondrial genome loss and elevating vacUolar pH increases proliferation after mtDNA deletion and reverses the protein import defect of mitochondria lacking DNA.