E
Esteban O. Mazzoni
Researcher at New York University
Publications - 78
Citations - 4805
Esteban O. Mazzoni is an academic researcher from New York University. The author has contributed to research in topics: Chromatin & Hox gene. The author has an hindex of 32, co-authored 66 publications receiving 4039 citations. Previous affiliations of Esteban O. Mazzoni include Columbia University & Columbia University Medical Center.
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Journal ArticleDOI
CTCF establishes discrete functional chromatin domains at the Hox clusters during differentiation
Varun Narendra,Varun Narendra,Pedro P. Rocha,Disi An,Ramya Raviram,Jane A. Skok,Esteban O. Mazzoni,Danny Reinberg,Danny Reinberg +8 more
TL;DR: It is demonstrated that the CCCTC-binding factor (CTCF) functions to insulate these adjacent yet antagonistic chromatin domains during embryonic stem cell differentiation into cervical motor neurons.
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Stochastic spineless expression creates the retinal mosaic for colour vision
TL;DR: It is suggested that the entire retinal mosaic required for colour vision is defined by the stochastic expression of a single transcription factor, Spineless.
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An Alternative Splicing Switch Regulates Embryonic Stem Cell Pluripotency and Reprogramming
Mathieu Gabut,Payman Samavarchi-Tehrani,Payman Samavarchi-Tehrani,Xinchen Wang,Valentina Slobodeniuc,Dave O'Hanlon,Hoon Ki Sung,Manuel Alvarez,Shaheynoor Talukder,Qun Pan,Esteban O. Mazzoni,Stéphane Nedelec,Hynek Wichterle,Knut Woltjen,Timothy P. Hughes,Peter W. Zandstra,Andras Nagy,Andras Nagy,Jeffrey L. Wrana,Jeffrey L. Wrana,Benjamin J. Blencowe +20 more
TL;DR: It is shown that the ESC-specific isoform of FOXP1 stimulates the expression of transcription factor genes required for pluripotency, including OCT4, NANOG, NR5A2, and GDF3, while concomitantly repressing genes necessary for ESC differentiation.
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Synergistic binding of transcription factors to cell-specific enhancers programs motor neuron identity
Esteban O. Mazzoni,Shaun Mahony,Shaun Mahony,Michael Closser,Carolyn A. Morrison,Stéphane Nedelec,Damian J. Williams,Disi An,David K. Gifford,Hynek Wichterle +9 more
TL;DR: In this paper, three transcription factors, Ngn2, Isl1 and Lhx3, were sufficient to program rapidly and efficiently spinal motor neuron identity when expressed in differentiating mouse embryonic stem cells.
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Homothorax Switches Function of Drosophila Photoreceptors from Color to Polarized Light Sensors
Mathias F. Wernet,Thomas Labhart,Franziska Baumann,Esteban O. Mazzoni,Franck Pichaud,Claude Desplan +5 more
TL;DR: It is shown that homothorax is both necessary and sufficient for inner PRs to adopt the polarization-sensitive DRA fate instead of the color-sensitive default state.