G
Gregory J. Heffron
Researcher at Harvard University
Publications - 14
Citations - 2626
Gregory J. Heffron is an academic researcher from Harvard University. The author has contributed to research in topics: PKM2 & Acetylation. The author has an hindex of 12, co-authored 14 publications receiving 2342 citations. Previous affiliations of Gregory J. Heffron include Beth Israel Deaconess Medical Center.
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Journal ArticleDOI
Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis
Jason W. Locasale,Alexandra R. Grassian,Tamar Melman,Costas A. Lyssiotis,Katherine R. Mattaini,Adam J. Bass,Adam J. Bass,Gregory J. Heffron,Christian M. Metallo,Taru A. Muranen,Hadar Sharfi,Atsuo T. Sasaki,Dimitrios Anastasiou,Edouard Mullarky,Natalie I. Vokes,Mika Sasaki,Rameen Beroukhim,Rameen Beroukhim,Gregory Stephanopoulos,Azra H. Ligon,Matthew Meyerson,Matthew Meyerson,Andrea L. Richardson,Lynda Chin,Gerhard Wagner,John M. Asara,Joan S. Brugge,Lewis C. Cantley,Matthew G. Vander Heiden,Matthew G. Vander Heiden +29 more
TL;DR: It is found that in some cancer cells a relatively large amount of glycolytic carbon is diverted into serine and glycine metabolism through phosphoglycerate dehydrogenase (PHGDH).
Journal ArticleDOI
Evidence for an Alternative Glycolytic Pathway in Rapidly Proliferating Cells
Matthew G. Vander Heiden,Matthew G. Vander Heiden,Jason W. Locasale,Jason W. Locasale,Kenneth D. Swanson,Hadar Sharfi,Gregory J. Heffron,Daniel Amador-Noguez,Heather R. Christofk,Gerhard Wagner,Joshua D. Rabinowitz,John M. Asara,Lewis C. Cantley,Lewis C. Cantley +13 more
TL;DR: It is demonstrated that phosphoenolpyruvate (PEP), the substrate for pyruVate kinase in cells, can act as a phosphate donor in mammalian cells because PEP participates in the phosphorylation of the glycolytic enzyme phosphoglycerate mutase (PGAM1) in PKM2-expressing cells.
Evidence for an Alternative Glycolytic Pathway in Rapidly Proliferating Cells
Matthew G. Vander Heiden,Matthew G. Vander Heiden,Jason W. Locasale,Jason W. Locasale,Kenneth D. Swanson,Hadar Sharfi,Gregory J. Heffron,Daniel Amador-Noguez,Heather R. Christofk,Gerhard Wagner,Joshua D. Rabinowitz,John M. Asara,Lewis C. Cantley,Lewis C. Cantley +13 more
TL;DR: In this paper, the authors demonstrate that phosphoenolpyruvate (PEP) can act as a phosphate donor in mammalian cells because PEP participates in the phosphorylation of the glycolytic enzyme phosphoglycerate mutase (PGAM1) in PKM2-expressing cells.
Journal ArticleDOI
Metabolic regulation of protein N-alpha-acetylation by Bcl-xL promotes cell survival.
Caroline H. Yi,Heling Pan,Jan Seebacher,Il Ho Jang,Sven G. Hyberts,Gregory J. Heffron,Matthew G. Vander Heiden,Matthew G. Vander Heiden,Matthew G. Vander Heiden,Renliang Yang,Fupeng Li,Jason W. Locasale,Hadar Sharfi,Bo Zhai,Ricard A. Rodriguez-Mias,Harry Luithardt,Lewis C. Cantley,Lewis C. Cantley,George Q. Daley,John M. Asara,John M. Asara,Steven P. Gygi,Gerhard Wagner,Chuan-Fa Liu,Junying Yuan +24 more
TL;DR: It is proposed that acetyl-CoA serves as a signaling molecule that couples apoptotic sensitivity to metabolism by regulating protein N-alpha-acetylation.
Metabolic Regulation of Protein N-Alpha-Acetylation by Bcl-xL Promotes Cell Survival
Caroline H. Yi,Heling Pan,Jan Seebacher,Il Ho Jang,Sven G. Hyberts,Gregory J. Heffron,Matthew G. Vander Heiden,Matthew G. Vander Heiden,Matthew G. Vander Heiden,Renliang Yang,Fupeng Li,Jason W. Locasale,Hadar Sharfi,Bo Zhai,Ricard A. Rodriguez-Mias,Harry Luithardt,Lewis C. Cantley,Lewis C. Cantley,George Q. Daley,John M. Asara,John M. Asara,Steven P. Gygi,Gerhard Wagner,Chuan-Fa Liu,Junying Yuan +24 more
TL;DR: In this paper, a biochemical assay was proposed to detect the acetylation status of proteins and demonstrate that protein N-alpha-acetylation is regulated by the availability of acetyl-CoA.