G
Gregory T. Motz
Researcher at University of Pennsylvania
Publications - 27
Citations - 3522
Gregory T. Motz is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Inflammation & NKG2D. The author has an hindex of 17, co-authored 27 publications receiving 2968 citations. Previous affiliations of Gregory T. Motz include University of Cincinnati Academic Health Center & University of Cincinnati.
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Journal ArticleDOI
Tumor endothelium FasL establishes a selective immune barrier promoting tolerance in tumors.
Gregory T. Motz,Stephen Santoro,Li-Ping Wang,Tom Garrabrant,Ricardo R. Lastra,Ian S. Hagemann,Priti Lal,Michael Feldman,Fabian Benencia,George Coukos,George Coukos +10 more
TL;DR: T tumor paracrine mechanisms establish a tumor endothelial death barrier, which has a critical role in establishing immune tolerance and determining the fate of tumors.
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T-Regulatory Cells: Key Players in Tumor Immune Escape and Angiogenesis
TL;DR: The ways in which Tregs suppress the antitumor immune response are discussed and elaborate on the recent discovery that T Regs make significant direct contributions to tumor angiogenesis.
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Deciphering and reversing tumor immune suppression.
TL;DR: The ways in which tumors exert immune suppression are reviewed and the new therapies that seek to reverse this phenomenon and promote anti-tumor immunity are highlighted.
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The parallel lives of angiogenesis and immunosuppression: cancer and other tales
Gregory T. Motz,George Coukos +1 more
TL;DR: It is suggested that the initiation of these responses is part of a physiological and homeostatic tissue repair programme, which can be co-opted in pathological states, notably by tumours.
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Heme oxygenase-1 induction by NRF2 requires inactivation of the transcriptional repressor BACH1
TL;DR: BACH1 confers an additional level of regulation to ARE-dependent genes that reveals a new dimension to the oxidative stress response and is compared with thioredoxin reductase 1.