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Ian S. Hagemann
Researcher at Washington University in St. Louis
Publications - 108
Citations - 4658
Ian S. Hagemann is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Cancer & Medicine. The author has an hindex of 24, co-authored 89 publications receiving 3648 citations. Previous affiliations of Ian S. Hagemann include University of Pennsylvania & Hospital of the University of Pennsylvania.
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Journal ArticleDOI
Tumour hypoxia promotes tolerance and angiogenesis via CCL28 and T reg cells
Andrea Facciabene,Xiaohui Peng,Ian S. Hagemann,Klara Balint,Andrea Barchetti,Li-Ping Wang,Phyllis A. Gimotty,C. Blake Gilks,Priti Lal,Lin Zhang,George Coukos +10 more
TL;DR: It is shown that tumour hypoxia promotes the recruitment of regulatory T (Treg) cells through induction of expression of the chemokine CC-chemokine ligand 28 (CCL28), which, in turn, promotes tumour tolerance and angiogenesis.
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Tumor endothelium FasL establishes a selective immune barrier promoting tolerance in tumors.
Gregory T. Motz,Stephen Santoro,Li-Ping Wang,Tom Garrabrant,Ricardo R. Lastra,Ian S. Hagemann,Priti Lal,Michael Feldman,Fabian Benencia,George Coukos,George Coukos +10 more
TL;DR: T tumor paracrine mechanisms establish a tumor endothelial death barrier, which has a critical role in establishing immune tolerance and determining the fate of tumors.
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Prognostic significance of tumor-infiltrating T cells in ovarian cancer: A meta-analysis
TL;DR: A meta-analysis of studies evaluating the prognostic value of tumor-infiltrating lymphocytes (TIL) on survival among women with ovarian cancer shows that intraepithelial TILs are a robust predictor of outcome in ovarian cancer.
Journal ArticleDOI
Clinical next-generation sequencing in patients with non-small cell lung cancer.
Ian S. Hagemann,Siddhartha Devarakonda,Christina M. Lockwood,David H. Spencer,Kalin Guebert,Andrew J. Bredemeyer,Hussam Al-Kateb,TuDung T. Nguyen,Eric J. Duncavage,Catherine E. Cottrell,Shashikant Kulkarni,Rakesh Nagarajan,Karen Seibert,Maria Q. Baggstrom,Saiama N. Waqar,John D. Pfeifer,Daniel Morgensztern,Ramaswamy Govindan +17 more
TL;DR: The feasibility and diagnostic yield of this assay in 381 consecutive patients with non–small cell lung cancer (NSCLC) is described.
Journal ArticleDOI
Validation of a next-generation sequencing assay for clinical molecular oncology.
Catherine E. Cottrell,Hussam Al-Kateb,Andrew J. Bredemeyer,Eric J. Duncavage,David H. Spencer,Haley J. Abel,Christina M. Lockwood,Ian S. Hagemann,Stephanie M. O’Guin,Lauren C. Burcea,Christopher S. Sawyer,Dayna M. Oschwald,Jennifer L. Stratman,Dorie A. Sher,Mark R. Johnson,Justin T. Brown,Paul F. Cliften,Bijoy George,Leslie D. McIntosh,Savita Shrivastava,TuDung T. Nguyen,Jacqueline E. Payton,Mark A. Watson,Seth D. Crosby,Richard D. Head,Robi D. Mitra,Rakesh Nagarajan,Shashikant Kulkarni,Karen Seibert,Herbert W. Virgin,Jeffrey Milbrandt,John D. Pfeifer +31 more
TL;DR: The WUCaMP assay is a robust and sensitive method to detect somatic variants of clinical significance in molecular oncology laboratories, with reduced time and cost of genetic analysis allowing for strategic patient management.