Ricardo R. Lastra

TL;DR: T tumor paracrine mechanisms establish a tumor endothelial death barrier, which has a critical role in establishing immune tolerance and determining the fate of tumors.

TL;DR: For the subset of women with microsatellite‐instable, metastatic disease, anti– programmed cell death protein 1 immunotherapy (pembrolizumab) is now approved by the US Food and Drug Administration, and numerous trials are attempting to build on this early success.

TL;DR: A label-free proteomic workflow is developed to analyse as few as 5,000 formalin-fixed, paraffin-embedded cells microdissected from each compartment and finds that stromal methyltransferase nicotinamide N-methyltransferase (NNMT) regulates the transition of normal fibroblasts to cancer-associated fibro Blasts through histone methylation and promotes ovarian cancer growth and metastasis.

TL;DR: Stable isotope labeling of amino acids in cell culture coupled with quantitative, label-free phosphoproteomics is used to study the bidirectional signaling in ovarian cancer cells and human-derived, cancer-associated fibroblasts after co-culture to suggest that glycogen is an energy source used by cancer cells to facilitate metastatic tumor growth.

TL;DR: Proteomics-based epithelial/mesenchymal stratification of cell lines and human tumours indicates a possible origin of HGSOC either from the fallopian tube or from the ovarian surface epithelium.