G
Guideng Li
Researcher at Peking Union Medical College
Publications - 45
Citations - 2016
Guideng Li is an academic researcher from Peking Union Medical College. The author has contributed to research in topics: Medicine & T cell. The author has an hindex of 21, co-authored 38 publications receiving 1468 citations. Previous affiliations of Guideng Li include University of California, Irvine & University of California.
Papers
More filters
Journal ArticleDOI
Cytosporone B is an agonist for nuclear orphan receptor Nur77
Yan-yan Zhan,Xiping Du,Hang-zi Chen,Jingjing Liu,Bi-xing Zhao,Danhong Huang,Guideng Li,Qingyan Xu,Ming-Qing Zhang,Bart C. Weimer,Dong Chen,Zhe Cheng,Lianru Zhang,Qinxi Li,Shaowei Li,Zhonghui Zheng,Siyang Song,Yaojian Huang,Zhiyun Ye,Wenjin Su,Sheng-Cai Lin,Yuemao Shen,Qiao Wu +22 more
TL;DR: The octaketide cytosporone B (Csn-B) is a naturally occurring agonist for Nur77 that induced apoptosis and retarded xenograft tumor growth by inducing Nur77 expression, translocating Nur77 to mitochondria to cause cytochrome c release and may be useful as a reagent to increase understanding of Nur77 biological function.
Journal ArticleDOI
BCR-signalling synergizes with TLR-signalling for induction of AID and immunoglobulin class-switching through the non-canonical NF-κB pathway
Egest J. Pone,Jinsong Zhang,Jinsong Zhang,Thach Mai,Clayton A. White,Guideng Li,John K Sakakura,Pina J. Patel,Ahmed A. Al-Qahtani,Ahmed A. Al-Qahtani,Hong Zan,Zhenming Xu,Paolo Casali +12 more
TL;DR: It is shown that BCR-signalling synergizes with Toll-like receptor (TLR) signalling to induce class switch DNA recombination, and by integrating signals of the non-canonical and canonical NF-κB pathways, BCR and TLRs synergize to induce AID and T-cell-independent class switchDNA recombination.
Journal ArticleDOI
Alternative mRNA splicing in cancer immunotherapy
TL;DR: The promise of analysing mRNA processing events in cancer cells, with an emphasis on mRNA splicing, for the identification of potential new targets for cancer immunotherapy is discussed.
Journal ArticleDOI
Functional TCR T cell screening using single-cell droplet microfluidics
Aude I. Segaliny,Guideng Li,Guideng Li,Lingshun Kong,Ci Ren,Xiaoming Chen,Jessica Wang,David Baltimore,Guikai Wu,Weian Zhao +9 more
TL;DR: The TCR screening prototype will facilitate immunotherapeutic screening and development of T cell therapies and use droplet microfluidics for functional screening and real-time monitoring of single TCR T cell activation upon recognition of target tumor cells.
Journal ArticleDOI
T cell antigen discovery via trogocytosis.
Guideng Li,Guideng Li,Michael T. Bethune,Stephanie Wong,Alok V. Joglekar,Michael T. Leonard,Jessica Wang,Jocelyn T. Kim,Donghui Cheng,Songming Peng,Jesse M. Zaretsky,Yapeng Su,Yicheng Luo,James R. Heath,James R. Heath,Antoni Ribas,Owen N. Witte,David Baltimore +17 more
TL;DR: A cell-based selection platform for TCR ligand discovery that exploits a membrane transfer phenomenon called trogocytosis and allows the identification of neoepitopes targeted by T cell receptors with high sensitivity is developed.