Q
Qinxi Li
Researcher at Xiamen University
Publications - 40
Citations - 2146
Qinxi Li is an academic researcher from Xiamen University. The author has contributed to research in topics: Signal transduction & Apoptosis. The author has an hindex of 20, co-authored 35 publications receiving 1784 citations. Previous affiliations of Qinxi Li include Princess Margaret Cancer Centre & Hong Kong University of Science and Technology.
Papers
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Journal ArticleDOI
GSK3-TIP60-ULK1 signaling pathway links growth factor deprivation to autophagy.
Shu-Yong Lin,Terytty Yang Li,Qing Liu,Cixiong Zhang,Xiaotong Li,Yan Chen,Shi-Meng Zhang,Guili Lian,Qi Liu,Ka Ruan,Zhen Wang,Chen-Song Zhang,Kun-Yi Chien,Jia-Wei Wu,Qinxi Li,Jiahuai Han,Sheng-Cai Lin +16 more
TL;DR: These findings uncover an activating pathway that integrates protein phosphorylation and acetylation to connect growth factor deprivation to autophagy when deprived of serum but not glucose.
Journal ArticleDOI
Cytosporone B is an agonist for nuclear orphan receptor Nur77
Yan-yan Zhan,Xiping Du,Hang-zi Chen,Jingjing Liu,Bi-xing Zhao,Danhong Huang,Guideng Li,Qingyan Xu,Ming-Qing Zhang,Bart C. Weimer,Dong Chen,Zhe Cheng,Lianru Zhang,Qinxi Li,Shaowei Li,Zhonghui Zheng,Siyang Song,Yaojian Huang,Zhiyun Ye,Wenjin Su,Sheng-Cai Lin,Yuemao Shen,Qiao Wu +22 more
TL;DR: The octaketide cytosporone B (Csn-B) is a naturally occurring agonist for Nur77 that induced apoptosis and retarded xenograft tumor growth by inducing Nur77 expression, translocating Nur77 to mitochondria to cause cytochrome c release and may be useful as a reagent to increase understanding of Nur77 biological function.
Journal ArticleDOI
Axin stimulates p53 functions by activation of HIPK2 kinase through multimeric complex formation.
Yanning Rui,Zhen Xu,Zhen Xu,Shu-Yong Lin,Qinxi Li,Qinxi Li,Hong-liang Rui,Wen Luo,Hai-Meng Zhou,Po Yan Cheung,Zhenguo Wu,Zhiyun Ye,Peng Li,Jiahuai Han,Jiahuai Han,Sheng-Cai Lin,Sheng-Cai Lin +16 more
TL;DR: The results show that Axin acts as a tumor suppressor by facilitating p53 function through integration of multiple factors.
Journal ArticleDOI
Mutant IDH1 Downregulates ATM and Alters DNA Repair and Sensitivity to DNA Damage Independent of TET2.
Satoshi Inoue,Satoshi Inoue,Wanda Y. Li,Wanda Y. Li,Alan Tseng,Alan Tseng,Alan Tseng,Isabel Beerman,Isabel Beerman,Andrew J. Elia,Andrew J. Elia,Sean C. Bendall,François Lemonnier,François Lemonnier,Ken Kron,Ken Kron,David W. Cescon,David W. Cescon,Zhenyue Hao,Zhenyue Hao,Evan F. Lind,Evan F. Lind,Naoya Takayama,Aline Cristiane Planello,Aline Cristiane Planello,Aline Cristiane Planello,Shu Yi Shen,Shu Yi Shen,Alan H. Shih,Dana M. Larsen,Qinxi Li,Qinxi Li,Bryan E. Snow,Bryan E. Snow,Andrew Wakeham,Andrew Wakeham,Jillian Haight,Jillian Haight,Chiara Gorrini,Chiara Gorrini,Christian Bassi,Christian Bassi,Kelsie L. Thu,Kelsie L. Thu,Kiichi Murakami,Kiichi Murakami,Alisha R. Elford,Alisha R. Elford,Takeshi Ueda,Takeshi Ueda,Kimberly Straley,Katharine E. Yen,Gerry Melino,Gerry Melino,Luisa Cimmino,Iannis Aifantis,Ross L. Levine,Daniel D. De Carvalho,Daniel D. De Carvalho,Mathieu Lupien,Mathieu Lupien,Derrick J. Rossi,Garry P. Nolan,Rob A. Cairns,Rob A. Cairns,Tak W. Mak,Tak W. Mak,Tak W. Mak +67 more
TL;DR: It is discovered that mice expressing endogenous mutant IDH1 have reduced numbers of hematopoietic stem cells (HSCs) in contrast to Tet2 knockout (TET2-KO) mice, which may have implications for treatment of IDH-mutant leukemia.
Journal ArticleDOI
Axin is a scaffold protein in TGF‐β signaling that promotes degradation of Smad7 by Arkadia
Wei Liu,Hong-liang Rui,Jifeng Wang,Shu-Yong Lin,Ying He,Mingliang Chen,Qinxi Li,Zhiyun Ye,Suping Zhang,Siu Chiu Chan,Ye-Guang Chen,Jiahuai Han,Jiahuai Han,Sheng-Cai Lin,Sheng-Cai Lin +14 more
TL;DR: It is shown that Axin activates TGF‐β signaling by forming a multimeric complex consisting of Smad7 and ubiquitin E3 ligase Arkadia, and coexpression of Wnt‐1 reduced Smad 7 ubiquitination by downregulating Axin levels, underscoring the importance of Axin as an intrinsic regulator in TGF-β signaling.