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Guido Ferlazzo
Researcher at University of Messina
Publications - 137
Citations - 9646
Guido Ferlazzo is an academic researcher from University of Messina. The author has contributed to research in topics: Interleukin 21 & Interleukin 12. The author has an hindex of 45, co-authored 126 publications receiving 8514 citations. Previous affiliations of Guido Ferlazzo include Cornell University & Wayne State University.
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Journal ArticleDOI
Human dendritic cells activate resting natural killer (NK) cells and are recognized via the NKp30 receptor by activated NK cells.
Guido Ferlazzo,Ming L. Tsang,Lorenzo Moretta,Lorenzo Moretta,Giovanni Melioli,Ralph M. Steinman,Christian Münz +6 more
TL;DR: It is suggested that DCs are able to control directly the expansion of NK cells and that the lysis of immature DCs can regulate the afferent limb of innate and adaptive immunity.
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The Abundant NK Cells in Human Secondary Lymphoid Tissues Require Activation to Express Killer Cell Ig-Like Receptors and Become Cytolytic
Guido Ferlazzo,Dolca Thomas,Shao Lee Lin,Kiera Goodman,Barbara Morandi,William A. Muller,Alessandro Moretta,Christian Münz +7 more
TL;DR: It is hypothesized that IL-2 can mobilize the NK cells of secondary lymphoid tissues to mediate natural killing during immune responses, and this newly characterized per forin− NK cell compartment in lymph nodes and related tissues probably outnumbers perforin+ NK cells.
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Distinct roles of IL-12 and IL-15 in human natural killer cell activation by dendritic cells from secondary lymphoid organs.
Guido Ferlazzo,Maggi Pack,Dolca Thomas,Casper Paludan,Dorothee Schmid,Till Strowig,Gwenola Bougras,William A. Muller,Lorenzo Moretta,Christian Münz +9 more
TL;DR: In this paper, the capacity of Dendritic cells to interact with NK cells in human lymphoid organs and identify the role of specific DC-derived cytokines was identified. And they demonstrated that DCs colocalize with NKs in the T cell areas of lymph nodes.
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CD56brightCD16− Killer Ig-Like Receptor− NK Cells Display Longer Telomeres and Acquire Features of CD56dim NK Cells upon Activation
Chiara Romagnani,Kerstin Juelke,Michela Falco,Barbara Morandi,A. D'Agostino,Roberta Costa,Giovanni Battista Ratto,Giuseppe Forte,Paolo Carrega,Gabrielle Lui,Romana Conte,Till Strowig,Alessandro Moretta,Christian Münz,Andreas Thiel,Lorenzo Moretta,Lorenzo Moretta,Guido Ferlazzo,Guido Ferlazzo +18 more
TL;DR: The results suggest that CD56brightCD16− KIR− and CD56dimCD16+KIR+/− NK cells correspond to sequential steps of differentiation and support the hypothesis that secondary lymphoid organs can be sites of NK cell final maturation and self-tolerance acquisition during immune reaction.
Journal ArticleDOI
NK cells at the interface between innate and adaptive immunity
Alessandro Moretta,Emanuela Marcenaro,Silvia Parolini,Guido Ferlazzo,Lorenzo Moretta,Lorenzo Moretta +5 more
TL;DR: This work has shown that the recruitment of CD56low CD16+ NK cells into inflamed peripheral tissues is orchestrated by various chemochines including the newly identified Chemerin and this process appears to play a crucial role in shaping both innate and adaptive immune responses.