D
Dorothee Schmid
Researcher at Rockefeller University
Publications - 9
Citations - 2810
Dorothee Schmid is an academic researcher from Rockefeller University. The author has contributed to research in topics: Antigen processing & MHC class II. The author has an hindex of 9, co-authored 9 publications receiving 2657 citations.
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Journal ArticleDOI
Endogenous MHC Class II Processing of a Viral Nuclear Antigen After Autophagy
Casper Paludan,Dorothee Schmid,Markus Landthaler,Martina Vockerodt,Dieter Kube,Thomas Tuschl,Christian Münz +6 more
TL;DR: Lysosomal processing after autophagy may contribute to MHC class II–restricted surveillance of long-lived endogenous antigens including nuclear proteins relevant to disease.
Journal ArticleDOI
Antigen-Loading Compartments for Major Histocompatibility Complex Class II Molecules Continuously Receive Input from Autophagosomes
TL;DR: It is suggested that macroautophagy constitutively and efficiently delivers cytosolic proteins for MHC class II presentation and can be harnessed for improved helper T cell stimulation.
Journal ArticleDOI
Distinct roles of IL-12 and IL-15 in human natural killer cell activation by dendritic cells from secondary lymphoid organs.
Guido Ferlazzo,Maggi Pack,Dolca Thomas,Casper Paludan,Dorothee Schmid,Till Strowig,Gwenola Bougras,William A. Muller,Lorenzo Moretta,Christian Münz +9 more
TL;DR: In this paper, the capacity of Dendritic cells to interact with NK cells in human lymphoid organs and identify the role of specific DC-derived cytokines was identified. And they demonstrated that DCs colocalize with NKs in the T cell areas of lymph nodes.
Journal ArticleDOI
Innate and adaptive immunity through autophagy.
Dorothee Schmid,Christian Münz +1 more
TL;DR: The importance of autophagy for cell survival has long been appreciated, but more recently, its essential role in both innate and adaptive immunity has been characterized in this article, where the immune system utilizes autophagic degradation of cytoplasmic material, to restrict intracellular pathogens and regulate adaptive immunity.
Journal ArticleDOI
β-amyloid is a substrate of autophagy in sporadic inclusion body myositis
Jan D. Lünemann,Jens Schmidt,Dorothee Schmid,K. Barthel,Arne Wrede,Marinos C. Dalakas,Christian Münz +6 more
TL;DR: In this article, the authors demonstrate that Atg8/LC3 colocalizes with APP in cultured human muscle cells and demonstrate that the autophagy pathway should be explored for its potential therapeutic merit in sIBM.