M
Mark J. Dickman
Researcher at University of Sheffield
Publications - 106
Citations - 6744
Mark J. Dickman is an academic researcher from University of Sheffield. The author has contributed to research in topics: RNA & Chemistry. The author has an hindex of 30, co-authored 92 publications receiving 5762 citations.
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Journal ArticleDOI
Small CRISPR RNAs guide antiviral defense in prokaryotes
Stan J. J. Brouns,Matthijs M. Jore,Magnus Lundgren,Edze R. Westra,Rik J. H. Slijkhuis,Ambrosius P. Snijders,Mark J. Dickman,Kira S. Makarova,Eugene V. Koonin,John van der Oost +9 more
TL;DR: The results demonstrate that the formation of mature guide RNAs by the CRISPR RNA endonuclease subunit of Cascade is a mechanistic requirement for antiviral defense.
Journal ArticleDOI
Structural basis for CRISPR RNA-guided DNA recognition by Cascade
Matthijs M. Jore,Magnus Lundgren,Magnus Lundgren,Esther van Duijn,Jelle B. Bultema,Edze R. Westra,Sakharam P Waghmare,Blake Wiedenheft,Blake Wiedenheft,Ümit Pul,Reinhild Wurm,Rolf Wagner,Marieke R Beijer,Arjan Barendregt,Kaihong Zhou,Kaihong Zhou,Ambrosius P. Snijders,Ambrosius P. Snijders,Mark J. Dickman,Jennifer A. Doudna,Jennifer A. Doudna,Egbert J. Boekema,Albert J. R. Heck,John van der Oost,Stan J. J. Brouns +24 more
TL;DR: The composition and low-resolution structure of Cascade is presented and it is shown how it recognizes double-stranded DNA targets in a sequence-specific manner and suggests that continuous invader DNA surveillance takes place without energy investment.
Journal ArticleDOI
RNA-guided complex from a bacterial immune system enhances target recognition through seed sequence interactions
Blake Wiedenheft,Esther van Duijn,Jelle B. Bultema,Sakharam P Waghmare,Kaihong Zhou,Arjan Barendregt,Wiebke Westphal,Albert J. R. Heck,Egbert J. Boekema,Mark J. Dickman,Jennifer A. Doudna +10 more
TL;DR: It is shown that the Csy proteins (Csy1–4) assemble into a 350 kDa ribonucleoprotein complex that facilitates target recognition by enhancing sequence-specific hybridization between the CRISPR RNA and complementary target sequences.
Journal ArticleDOI
Zebularine: A Novel DNA Methylation Inhibitor that Forms a Covalent Complex with DNA Methyltransferases
TL;DR: The interaction between the C5 MTase from Haemophilus haemolyticus and an oligodeoxynucleotide duplex containing 2-H pyrimidinone provides a molecular explanation for the mechanism of action of the anti-cancer drug zebularine.
Journal ArticleDOI
Sequestration of multiple RNA recognition motif-containing proteins by C9orf72 repeat expansions.
Johnathan Cooper-Knock,Matthew J. Walsh,Adrian Higginbottom,J. Robin Highley,Mark J. Dickman,Dieter Edbauer,Paul G. Ince,Stephen B. Wharton,Stuart A. Wilson,Janine Kirby,Guillaume M. Hautbergue,Pamela J. Shaw +11 more
TL;DR: Using RNA pulldown and immunohistochemistry in ALS biosamples, Cooper-Knock et al. identify proteins that bind to the repeat expansions in C9orf72 that cause familial amyotrophic lateral sclerosis and frontotemporal dementia.