G
Gunilla B. Karlsson Hedestam
Researcher at Karolinska Institutet
Publications - 142
Citations - 5026
Gunilla B. Karlsson Hedestam is an academic researcher from Karolinska Institutet. The author has contributed to research in topics: Antibody & Medicine. The author has an hindex of 36, co-authored 108 publications receiving 4016 citations. Previous affiliations of Gunilla B. Karlsson Hedestam include Swedish Institute.
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Journal ArticleDOI
The challenges of eliciting neutralizing antibodies to HIV-1 and to influenza virus
Gunilla B. Karlsson Hedestam,Gunilla B. Karlsson Hedestam,Ron A. M. Fouchier,Sanjay Phogat,Dennis R. Burton,Joseph Sodroski,Richard T. Wyatt +6 more
TL;DR: The difficulties of achieving broad HIV-1 neutralization in the context of both the effective annual human influenza virus vaccine and the need to develop a pandemic influenza vaccine are discussed.
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An alpaca nanobody neutralizes SARS-CoV-2 by blocking receptor interaction.
Leo Hanke,Laura Vidakovics Perez,Daniel J. Sheward,Daniel J. Sheward,Hrishikesh Das,Tim Schulte,Ainhoa Moliner-Morro,Martin Corcoran,Adnane Achour,Gunilla B. Karlsson Hedestam,B. Martin Hallberg,Ben Murrell,Gerald M. McInerney +12 more
TL;DR: While fusion to an Fc domain renders Ty1 extremely potent, Ty1 neutralizes SARS-CoV-2 spike pseudovirus as a 12.8 kDa nanobody, which can be expressed in high quantities in bacteria, presenting opportunities for manufacturing at scale.
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Production of individualized V gene databases reveals high levels of immunoglobulin genetic diversity.
Martin Corcoran,Ganesh E. Phad,Néstor Vázquez Bernat,Christiane Stahl-Hennig,Noriyuki Sumida,Mats Persson,Marcel Martin,Gunilla B. Karlsson Hedestam +7 more
TL;DR: IgDiscover analysis of the allelic content of the Indian and Chinese-origin rhesus macaques reveals high levels of immunoglobulin gene diversity in this species, demonstrating the power of IgDiscover as a germline V gene discovery tool.
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Sequestration of G3BP coupled with efficient translation inhibits stress granules in Semliki Forest virus infection
Marc D. Panas,Margus Varjak,Aleksei Lulla,Kai Er Eng,Andres Merits,Gunilla B. Karlsson Hedestam,Gerald M. McInerney +6 more
TL;DR: A novel mechanism for SG disruption is described usingSemliki Forest virus nsP3 sequesters G3BP to inhibit stress granule formation on viral mRNAs and the efficient translation of viral mRNA containing a translation enhancer element assists disruption of SGs in infected cells.
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A novel quantitative flow cytometry-based assay for autophagy.
TL;DR: A straightforward assay for autophagy is presented which combines the sensitivity of the EGFP-LC3 reporter protein with the throughput capacity and quantitative power of flow cytometry and is extended to the detection of autophagosome formation in non-transfected cells.