G
Gunnar Dittmar
Researcher at University of Luxembourg
Publications - 155
Citations - 13724
Gunnar Dittmar is an academic researcher from University of Luxembourg. The author has contributed to research in topics: Ubiquitin & Biology. The author has an hindex of 35, co-authored 127 publications receiving 11002 citations. Previous affiliations of Gunnar Dittmar include Charité & Cardiff University.
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Journal ArticleDOI
Deregulated Splicing Is a Major Mechanism of RNA-Induced Toxicity in Huntington's Disease.
Judith Schilling,Meike Broemer,Ilian Atanassov,Yvonne Duernberger,Ina Vorberg,Ina Vorberg,Christoph Dieterich,Alina Dagane,Gunnar Dittmar,Erich E. Wanker,Willeke M. C. van Roon-Mom,Jennifer Winter,Sybille Krauß +12 more
TL;DR: The analysis of proteins that preferentially bind mutant HTT RNA using a mass spectrometry approach suggests that deregulated splicing is a prominent mechanism of RNA-induced toxicity in HD.
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RNF4-Dependent Oncogene Activation by Protein Stabilization
Jane Joy Thomas,Mona Abed,Julian Heuberger,Rostislav Novak,Yaniv Zohar,Ángela Patricia Beltrán López,Julie S. Trausch-Azar,Ma. Xenia G. Ilagan,David Benhamou,Gunnar Dittmar,Raphael Kopan,Walter Birchmeier,Alan L. Schwartz,Amir Orian +13 more
TL;DR: RNF4-dependent ubiquitylation translates transient phosphorylation signal(s) into long-term protein stabilization, resulting in enhanced oncoprotein activation.
Journal ArticleDOI
SORCS1 and SORCS3 control energy balance and orexigenic peptide production
Aygul Subkhangulova,Anna R. Malik,Guido Hermey,Oliver Popp,Gunnar Dittmar,Thomas Rathjen,Matthew N. Poy,Alexander Stumpf,Prateep Beed,Dietmar Schmitz,Tilman Breiderhoff,Thomas E. Willnow +11 more
TL;DR: A previously unknown function of these receptors in central control of metabolism is document using mouse models with individual or dual receptor deficiencies and highlights a novel concept in regulation of the melanocortin system.
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Muscle RING‐finger 2 and 3 maintain striated‐muscle structure and function
Dörte Lodka,Aanchal Pahuja,Cornelia Geers-Knörr,Renate J. Scheibe,Marcel Nowak,Jida Hamati,Clemens Köhncke,Bettina Purfürst,Tamara Kanashova,Sibylle Schmidt,David J. Glass,Ingo Morano,Arnd Heuser,Theresia Kraft,Rhonda Bassel-Duby,Eric N. Olson,Gunnar Dittmar,Thomas Sommer,Jens Fielitz,Jens Fielitz +19 more
TL;DR: This work investigated cooperative function of MuRF2 and MuRF3 in the skeletal muscle and the heart in vivo and implicated in sarcomere formation with noticeable functional redundancy.
Journal ArticleDOI
Proteomic techniques to probe the ubiquitin landscape.
TL;DR: This review seeks to provide an overview of the many MS‐based proteomics techniques available for exploring this dynamic field, with particular focus on characterization of the interubiquitin connectivity in ubiquitin polymers.