Showing papers by "Guolan Dou published in 2008"
TL;DR: A series of pyrimido derivatives were synthesized via the three-component reaction of an aldehyde, 6-aminopyrimidine-2,4-dione and 5,5-dimethyl-1,3-cyclohexanedione or 1,3indanedione in ionic liquid 1-n-butyl-3-methylimidazolium bromide ([bmim]Br).
59 citations
TL;DR: Compared with the classical synthetic method, this new method has the advantages of short reaction time, high yields, convenient manipulation, and high regioselectivity.
Abstract: 1,2,3,5-Tetrasubstituted and 1,2,3,4,5-pentasubstituted pyrroles may be synthesized through three-component reaction of 1,3-diketones, aldehydes, and amines induced by low-valent titanium reagent. High regioselectivity was achieved. Compared with the classical synthetic method, this new method has the advantages of short reaction time (15 min), high yields, convenient manipulation, and high regioselectivity.
54 citations
TL;DR: In this article, the preparation of 3,3,6,6-tetramethyl, 9,10-diaryl and 5,5-dimethyl-1,3-cyclohexanedione in 1-n-butyl-3-methylimidazolium bromide ([bmim]Br) is described.
52 citations
TL;DR: In this paper, the role of stannous chloride is acting as both reductive agent and catalyst in the synthesis of quinoxaline derivatives, which has the advantages of accessible starting materials, convenient manipulation, short reaction time and high yields.
35 citations
TL;DR: In this paper, a mild, efficient and novel synthesis of 2,3-dihydro-1-hydroxyquinazolin-4(1 H)-ones via cyclization of 2-nitrobenz-amides and ketones induced by tin(II) chloride dihydrate is described.
Abstract: A mild, efficient and novel synthesis of 2,3-dihydro-1-hydroxyquinazolin-4(1 H)-ones via cyclization of 2-nitrobenz-amides and ketones induced by tin(II) chloride dihydrate is described. This new method has the advantages of accessible starting materials, convenient manipulation, short reaction times, and high yields.
14 citations
12 citations
9 citations
TL;DR: In this article, a short and efficient synthesis of substituted pyrroles was accomplished in good yields via the novel coupling cyclization reaction of 1,3-diketones with imines promoted by low-valent titanium reagent.
Abstract: A short and efficient synthesis of substituted pyrroles was accomplished in good yields via the novel coupling cyclization reaction of 1,3-diketones with imines promoted by low-valent titanium reagent. High regioselectivity was achieved and the structures of two of the products were confirmed by X-ray diffraction studies.
1 citations
TL;DR: In this paper, a facile synthetic method using low-valent titanium reagent (TiCl 4 /Zn system) to promote the novel reductive cyclization of 2-nitrobenzamides and triphosgene is described.
Abstract: A facile synthetic method using low-valent titanium reagent (TiCl 4 /Zn system) to promote the novel reductive cyclization of 2-nitrobenzamides and triphosgene is described. Sequentially, a series of quinazoline-2,4-diones were synthesized in good yields.
1 citations
TL;DR: In this article, a mild, efficient and novel synthesis of 2-aryl-2H-indazoles via cyclization of 2nitrobenzylamines promoted by SnCl 2 ·2H 2 O has been described.
Abstract: A mild, efficient, and novel synthesis of 2-aryl-2H-indazoles via cyclization of 2-nitrobenzylamines promoted by SnCl 2 ·2H 2 O has been described. This method applies to a wide scope of substrates containing electron-donating and electron-withdrawing substituents.
1 citations
TL;DR: In this article, a mild, efficient and novel synthesis of 2,3-dihydro-1-hydroxyquinazolin-4(1 H)-ones via cyclization of 2-nitrobenz-amides and ketones induced by tin(II) chloride dihydrate is described.
Abstract: A mild, efficient and novel synthesis of 2,3-dihydro-1-hydroxyquinazolin-4(1 H)-ones via cyclization of 2-nitrobenz-amides and ketones induced by tin(II) chloride dihydrate is described. This new method has the advantages of accessible starting materials, convenient manipulation, short reaction times, and high yields.
TL;DR: In this article, a short and facile synthesis of a series of 3-aryl-3,4-dihydroquinazolin-2(lift-ones) was accomplished in good yields via the novel reductive cyclisation of 2-nitrobenzylamines with bis(trichloromethyl)carbonate (triphosgene) promoted by TiCl 4 /Sm system.
Abstract: A short and facile synthesis of a series of 3-aryl-3,4-dihydroquinazolin-2(lift-ones was accomplished in good yields via the novel reductive cyclisation of 2-nitrobenzylamines with bis(trichloromethyl)carbonate (triphosgene) promoted by TiCl 4 /Sm system. The structures of the products were characterised by IR, 1 H NMR and elemental analysis and the structure of 3a was confirmed by X-ray diffraction analysis.