Journal ArticleDOI
Highly regioselective synthesis of polysubstituted pyrroles through three-component reaction induced by low-valent titanium reagent.
TLDR
Compared with the classical synthetic method, this new method has the advantages of short reaction time, high yields, convenient manipulation, and high regioselectivity.Abstract:
1,2,3,5-Tetrasubstituted and 1,2,3,4,5-pentasubstituted pyrroles may be synthesized through three-component reaction of 1,3-diketones, aldehydes, and amines induced by low-valent titanium reagent. High regioselectivity was achieved. Compared with the classical synthetic method, this new method has the advantages of short reaction time (15 min), high yields, convenient manipulation, and high regioselectivity.read more
Citations
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Journal ArticleDOI
Transition Metal-Mediated Synthesis of Monocyclic Aromatic Heterocycles
TL;DR: The present review is a transition metal-catalyzed synthesis of aromatic monocyclic heterocycles, aiming at achieving greater levels of molecular complexity and better functional group compatibilities in a convergent and atom economical fashions from readily accessible starting materials and under mild reaction conditions.
Journal ArticleDOI
Multicomponent reactions for the synthesis of pyrroles
TL;DR: Multicomponent reactions are one of the most interesting concepts in modern synthetic chemistry and provide an attractive entry into pyrrole derivatives, which are very important heterocycles from many points of view.
Journal ArticleDOI
Multicomponent Reactions for the Synthesis of Heterocycles
TL;DR: Recent advances on multicomponent domino reactions for the construction of five-, six-, and seven-membered heterocyclic skeletons and their multicyclic derivatives are covered.
Journal ArticleDOI
Iron(III)-Catalyzed Four-Component Coupling Reaction of 1,3-Dicarbonyl Compounds, Amines, Aldehydes, and Nitroalkanes: A Simple and Direct Synthesis of Functionalized Pyrroles
TL;DR: This strategy demonstrated four-component coupling reactions of 1,3-dicarbonyl compounds, amines, aromatic aldehydes, and nitroalkanes without an inert atmosphere to provide an alternative approach for easy access of highly substituted pyrroles in moderate to very good yields.
Journal ArticleDOI
Rapid and efficient ultrasound-assisted method for the combinatorial synthesis of spiro[indoline-3,4'-pyrano[2,3-c]pyrazole] derivatives.
Yi Zou,Yu Hu,Hai Liu,Daqing Shi +3 more
TL;DR: This one-pot synthesis of spiro[indoline-3,4'-pyrano[2,3-c]pyrazole] derivatives by four-component reaction of hydrazine, β-keto ester, isatin, and malononitrile catalyzed by piperidine under ultrasound irradiation is described.
References
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Book
Comprehensive Heterocyclic Chemistry II
TL;DR: In this article, the CHEC III is organized in 15 volumes and closely follows the organization used in the previous edition: Volumes 1 and 2: Cover respectively three and four-membered heterocycles, together with all fused systems containing a three- or four-measured heterocyclic ring.
Journal ArticleDOI
Multicomponent Reactions with Isocyanides.
Alexander Dömling,Ivar Ugi +1 more
TL;DR: MCRs and especially MCRs with isocyanides offer many opportunities to attain new reactions and basic structures, however, this requires that the chemist learns the "language" of M CRs, something that this review wishes to stimulate.
Journal ArticleDOI
Asymmetric multicomponent reactions (amcrs): the new frontier
Diego J. Ramón,Miguel Yus +1 more
TL;DR: Asymmetric multicomponent reactions involve the preparation of chiral compounds by the reaction of three or more reagents added simultaneously and has some advantages over classic divergent reaction strategies, such as lower costs, time, and energy, as well as environmentally friendlier aspects.
Journal ArticleDOI
Maximizing Synthetic Efficiency: Multi-Component Transformations Lead the Way
TL;DR: Over the last five years, industrial and academic researchers have made the unique exploratory power of some reactions into one of the most efficient and cost-effective tools for combinatorial and parallel synthesis.
Journal ArticleDOI
Recent Advances in Solution-Phase Multicomponent Methodology for the Synthesis of Heterocyclic Compounds
TL;DR: A review of solution-phase multi-component procedures for the synthesis of heterocyclic compounds can be found in this paper, where the authors give an overview of the progress made in the past decade.