G
Guoqing Cao
Researcher at University of Texas Southwestern Medical Center
Publications - 7
Citations - 757
Guoqing Cao is an academic researcher from University of Texas Southwestern Medical Center. The author has contributed to research in topics: Scavenger receptor & Gene. The author has an hindex of 7, co-authored 7 publications receiving 745 citations.
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Journal ArticleDOI
Structure and localization of the human gene encoding sr-bi/cla-1: evidence for transcriptional control by steroidogenic factor 1
Guoqing Cao,Christine Kim Garcia,Kathleen Wyne,Roger A. Schultz,Keith L. Parker,Helen H. Hobbs +5 more
TL;DR: RNA blot analysis of human SR-BI tissues reveals an expression pattern similar to that described previously for rodents with the highest levels of mRNA in the adrenal gland, ovary, and liver, and evidence that it is regulated by the transcription factor, steroidogenic factor 1 (SF-1).
Journal ArticleDOI
Structure of the Human Gene Encoding Sterol Regulatory Element Binding Protein 2 (SREBF2)
TL;DR: Analysis of the 5'-flanking regions of SREBF2 provides support that these two transcription factors, though similar in their coding sequence and overall gene structure, have different physiological roles.
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Scavenger Receptor, Class B, Type I-dependent Stimulation of Cholesterol Esterification by High Density Lipoproteins, Low Density Lipoproteins, and Nonlipoprotein Cholesterol
TL;DR: It is concluded that, in the absence of the LDL receptor, overexpression of SR-BI can mediate significant transport of sterols between lipoproteins and the endoplasmic reticulum of cells.
Journal ArticleDOI
Developmental and hormonal regulation of murine scavenger receptor, class B, type 1.
Guoqing Cao,Liping Zhao,Herbert Stangl,Tomonobu Hasegawa,James A. Richardson,Keith L. Parker,Helen H. Hobbs +6 more
TL;DR: In vivo evidence that steroidogenic factor-1 (SF-1) regulates SR-BI is provided and trophic hormones can override the suppressive effect of cholesterol onSR-BI expression, thus ensuring that steroidogenesis is maintained during stress.
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Sterol regulation of scavenger receptor class B type I in macrophages
TL;DR: SR-BI levels in macrophages are responsive to changes in intracellular sterol content and that these sterol-associated changes are not mediated by LXR and are unlikely to be mediated by an SREBP pathway.