C
Christine Kim Garcia
Researcher at Columbia University
Publications - 87
Citations - 11357
Christine Kim Garcia is an academic researcher from Columbia University. The author has contributed to research in topics: Pulmonary fibrosis & Idiopathic pulmonary fibrosis. The author has an hindex of 36, co-authored 67 publications receiving 8109 citations. Previous affiliations of Christine Kim Garcia include University of Texas Southwestern Medical Center & University of Texas at Dallas.
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Journal ArticleDOI
Post-acute COVID-19 syndrome.
Ani Nalbandian,Kartik Sehgal,Kartik Sehgal,Aakriti Gupta,Aakriti Gupta,Mahesh V. Madhavan,Claire McGroder,Jacob S. Stevens,Joshua R. Cook,Anna S. Nordvig,Daniel Shalev,Tejasav S. Sehrawat,Neha Ahluwalia,Behnood Bikdeli,Donald Dietz,Caroline Der-Nigoghossian,Nadia Liyanage-Don,Gregg F. Rosner,Elana J. Bernstein,Sumit Mohan,Akinpelumi A Beckley,David S. Seres,Toni K. Choueiri,Toni K. Choueiri,Nir Uriel,John C. Ausiello,Domenico Accili,Daniel E. Freedberg,Matthew R. Baldwin,Allan Schwartz,Daniel Brodie,Christine Kim Garcia,Mitchell S.V. Elkind,Jean M. Connors,Jean M. Connors,John P. Bilezikian,Donald W. Landry,Elaine Wan +37 more
TL;DR: A comprehensive review of the current literature on post-acute COVID-19, its pathophysiology and its organ-specific sequelae is provided in this paper, where the authors discuss relevant considerations for the multidisciplinary care of COPD survivors and propose a framework for the identification of those at high risk for COPD and their coordinated management through dedicated COPD clinics.
Journal ArticleDOI
Low LDL cholesterol in individuals of African descent resulting from frequent nonsense mutations in PCSK9.
Jonathan Cohen,Alexander Pertsemlidis,Ingrid K. Kotowski,Randall B. Graham,Christine Kim Garcia,Helen H. Hobbs +5 more
TL;DR: In this article, the coding region of PCSK9 was sequenced in 128 subjects (50% African American) with low plasma levels of LDL and found two nonsense mutations (Y142X and C679X) were common in African Americans (combined frequency, 2%) but rare in European Americans (< 0.1%).
Journal ArticleDOI
Adult-onset pulmonary fibrosis caused by mutations in telomerase
Kalliopi D. Tsakiri,Jennifer T. Cronkhite,Phillip J. Kuan,Chao Xing,Ganesh Raghu,Jonathan C. Weissler,Randall L. Rosenblatt,Jerry W. Shay,Christine Kim Garcia +8 more
TL;DR: Linkage to map the disease gene in two families to chromosome 5 revealed mutations in TERT or TERC that result in telomere shortening over time confer a dramatic increase in susceptibility to adult-onset IPF.
Journal ArticleDOI
Genome-wide association study identifies multiple susceptibility loci for pulmonary fibrosis.
Tasha E. Fingerlin,Elissa Murphy,Weiming Zhang,Anna L. Peljto,Kevin K. Brown,Mark P. Steele,James E. Loyd,Gregory P. Cosgrove,David A. Lynch,Steve D. Groshong,Harold R. Collard,Paul J. Wolters,Williamson Z. Bradford,Karl Kossen,Scott D. Seiwert,Roland M. du Bois,Christine Kim Garcia,Megan S. Devine,Gunnar Gudmundsson,Helgi J Isaksson,Naftali Kaminski,Yingze Zhang,Kevin F. Gibson,Lisa Lancaster,Joy D. Cogan,Wendi R. Mason,Toby M. Maher,Philip L. Molyneaux,Athol U. Wells,Miriam F. Moffatt,Moisés Selman,Annie Pardo,Dong Soon Kim,James D. Crapo,Barry J. Make,Elizabeth A. Regan,Dinesha Walek,Jerry Daniel,Yoichiro Kamatani,Diana Zelenika,Keith P Smith,David McKean,Brent S. Pedersen,Janet Talbert,Ravin N. Kidd,Cheryl Markin,Kenneth B. Beckman,Mark Lathrop,Mark Lathrop,Marvin I. Schwarz,David A. Schwartz +50 more
TL;DR: The results suggest that genes involved in host defense, cell-cell adhesion and DNA repair contribute to risk of fibrotic IIPs.
Journal ArticleDOI
Autosomal recessive hypercholesterolemia caused by mutations in a putative LDL receptor adaptor protein.
Christine Kim Garcia,Kenneth R. Wilund,Marcello Arca,Giovanni Zuliani,Renato Fellin,Mario Maioli,Sebastiano Calandra,Stefano Bertolini,Fausto Cossu,Nick V. Grishin,Robert Barnes,Jonathan Cohen,Helen H. Hobbs +12 more
TL;DR: ARH appears to have a tissue-specific role in LDLR function, as it is required in liver but not in fibroblasts, and six mutations in a gene encoding a putative adaptor protein (ARH) are identified.