G
Guotong Fu
Researcher at St. Jude Children's Research Hospital
Publications - 3
Citations - 113
Guotong Fu is an academic researcher from St. Jude Children's Research Hospital. The author has contributed to research in topics: Immune system & Immune receptor. The author has an hindex of 2, co-authored 3 publications receiving 12 citations.
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Journal ArticleDOI
In vivo CRISPR screening reveals nutrient signaling processes underpinning CD8+ T cell fate decisions.
Hongling Huang,Peipei Zhou,Jun Wei,Lingyun Long,Hao Shi,Yogesh Dhungana,Nicole M. Chapman,Guotong Fu,Jordy Saravia,Jana L. Raynor,Shaofeng Liu,Gustavo Palacios,Yong-Dong Wang,Chenxi Qian,Jiyang Yu,Hongbo Chi +15 more
TL;DR: In this article, metabolic factors in fate determination of TEFF and TMEM cells using in-vivo pooled CRISPR screening were investigated, focusing on negative regulators of TMEM responses.
Journal ArticleDOI
Metabolic control of TFH cells and humoral immunity by phosphatidylethanolamine.
Guotong Fu,Clifford S. Guy,Nicole M. Chapman,Gustavo Palacios,Jun Wei,Peipei Zhou,Lingyun Long,Yong-Dong Wang,Chenxi Qian,Yogesh Dhungana,Hongling Huang,Anil Kc,Hao Shi,Sherri Rankin,Scott A. Brown,Amanda Johnson,Randall Wakefield,Camenzind G. Robinson,Xueyan Liu,Anthony Sheyn,Anthony Sheyn,Jiyang Yu,Suzanne Jackowski,Hongbo Chi +23 more
TL;DR: In this paper, the cytidine diphosphate-ethanolamine pathway co-ordinates the expression and localization of CXCR5 with the responses of TFH cells and humoral immunity.
Journal ArticleDOI
CRISPR screens unveil signal hubs for nutrient licensing of T cell immunity
Lingyun Long,Jun Wei,Seon Ah Lim,Jana L. Raynor,Hao Shi,Jon P. Connelly,Hong Wang,Cliff Guy,Boer Xie,Nicole M. Chapman,Guotong Fu,Yanyan Wang,Hongling Huang,Wei Su,Jordy Saravia,Isabel Risch,Yong-Dong Wang,Yuxin Li,Mingming Niu,Yogesh Dhungana,Anil Kc,Peipei Zhou,Peter Vogel,Jiyang Yu,Shondra M. Pruett-Miller,Junmin Peng,Hongbo Chi +26 more
TL;DR: In this paper, the authors used genome-wide CRISPR screening combined with protein-protein interaction networks to identify regulatory modules that mediate immune receptor-and nutrient-dependent signalling to mTORC1 in mouse regulatory T (Treg) cells.