Hao Shi

TL;DR: In this article, the authors show that the activity of sterol-regulatory-element-binding proteins (SREBPs) is upregulated in intratumoral Treg cells and that deletion of SREBP-cleavage-activating protein (SCAP) in these cells inhibits tumour growth and boosts immunotherapy.

TL;DR: It is reported that Mst1 regulates Foxp3 expression and Treg development/function and inhibits autoimmunity through modulating Foxo1 and Foxo3 (Foxo1/3) stability and shed new light on understanding and designing better therapeutic strategies for MST1 deficiency–mediated human immunodeficiency syndrome.

TL;DR: It is demonstrated that the serine/threonine kinases Mst1 and Mst2 sense IL‐2 signals to promote STAT5 activation to maintain Treg cell homeostasis, lineage stability, and the highly suppressive phosphorylated‐STAT5+ Tregcell subpopulation.

TL;DR: It is shown that amino acids license Treg cell function by priming and sustaining TCR-induced mTORC1 activity, which reveals a crucial requirement of amino acid signaling for licensing and sustaining m TORC1 activation and functional programming of Treg cells.

TL;DR: The results indicate that developmental arrest in T-ALL drives differential activation of preTCR-LCK and BCL2 signaling in this leukemia, providing unique opportunities for targeted therapy.