P
Peipei Zhou
Researcher at St. Jude Children's Research Hospital
Publications - 6
Citations - 232
Peipei Zhou is an academic researcher from St. Jude Children's Research Hospital. The author has contributed to research in topics: PI3K/AKT/mTOR pathway & mTORC1. The author has an hindex of 3, co-authored 6 publications receiving 48 citations.
Papers
More filters
Journal ArticleDOI
mTOR signaling at the crossroads of environmental signals and T-cell fate decisions
TL;DR: An updated overview of the roles of mTOR in T‐cell development, homeostasis, activation, and effector‐cell fate decisions, as well as its important impacts on the suppressive activity of regulatory T cells are provided.
Journal ArticleDOI
In vivo CRISPR screening reveals nutrient signaling processes underpinning CD8+ T cell fate decisions.
Hongling Huang,Peipei Zhou,Jun Wei,Lingyun Long,Hao Shi,Yogesh Dhungana,Nicole M. Chapman,Guotong Fu,Jordy Saravia,Jana L. Raynor,Shaofeng Liu,Gustavo Palacios,Yong-Dong Wang,Chenxi Qian,Jiyang Yu,Hongbo Chi +15 more
TL;DR: In this article, metabolic factors in fate determination of TEFF and TMEM cells using in-vivo pooled CRISPR screening were investigated, focusing on negative regulators of TMEM responses.
Journal ArticleDOI
Metabolic control of TFH cells and humoral immunity by phosphatidylethanolamine.
Guotong Fu,Clifford S. Guy,Nicole M. Chapman,Gustavo Palacios,Jun Wei,Peipei Zhou,Lingyun Long,Yong-Dong Wang,Chenxi Qian,Yogesh Dhungana,Hongling Huang,Anil Kc,Hao Shi,Sherri Rankin,Scott A. Brown,Amanda Johnson,Randall Wakefield,Camenzind G. Robinson,Xueyan Liu,Anthony Sheyn,Anthony Sheyn,Jiyang Yu,Suzanne Jackowski,Hongbo Chi +23 more
TL;DR: In this paper, the cytidine diphosphate-ethanolamine pathway co-ordinates the expression and localization of CXCR5 with the responses of TFH cells and humoral immunity.
Journal ArticleDOI
Protein Prenylation Drives Discrete Signaling Programs for the Differentiation and Maintenance of Effector Treg Cells
Wei Su,Wei Su,Nicole M. Chapman,Jun Wei,Hu Zeng,Yogesh Dhungana,Hao Shi,Jordy Saravia,Peipei Zhou,Lingyun Long,Sherri Rankin,Anil Kc,Peter Vogel,Hongbo Chi +13 more
TL;DR: It is shown that isoprenoid-dependent posttranslational lipid modifications dictate eTreg cell accumulation and function by intersecting with TCR-induced intracellular signaling.
Journal ArticleDOI
CRISPR screens unveil signal hubs for nutrient licensing of T cell immunity
Lingyun Long,Jun Wei,Seon Ah Lim,Jana L. Raynor,Hao Shi,Jon P. Connelly,Hong Wang,Cliff Guy,Boer Xie,Nicole M. Chapman,Guotong Fu,Yanyan Wang,Hongling Huang,Wei Su,Jordy Saravia,Isabel Risch,Yong-Dong Wang,Yuxin Li,Mingming Niu,Yogesh Dhungana,Anil Kc,Peipei Zhou,Peter Vogel,Jiyang Yu,Shondra M. Pruett-Miller,Junmin Peng,Hongbo Chi +26 more
TL;DR: In this paper, the authors used genome-wide CRISPR screening combined with protein-protein interaction networks to identify regulatory modules that mediate immune receptor-and nutrient-dependent signalling to mTORC1 in mouse regulatory T (Treg) cells.