G
Gurol Tuncman
Researcher at Harvard University
Publications - 18
Citations - 9161
Gurol Tuncman is an academic researcher from Harvard University. The author has contributed to research in topics: Insulin resistance & Insulin. The author has an hindex of 14, co-authored 17 publications receiving 8550 citations. Previous affiliations of Gurol Tuncman include Ankara University.
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Journal ArticleDOI
Endoplasmic Reticulum Stress Links Obesity, Insulin Action, and Type 2 Diabetes
Umut Ozcan,Qiong Cao,Erkan Yilmaz,Ann-Hwee Lee,Neal N. Iwakoshi,Esra Özdelen,Gurol Tuncman,Cem Z. Görgün,Laurie H. Glimcher,Gökhan S. Hotamisligil +9 more
TL;DR: It is shown that obesity causes endoplasmic reticulum (ER) stress, which leads to suppression of insulin receptor signaling through hyperactivation of c-Jun N-terminal kinase (JNK) and subsequent serine phosphorylation of insulin receptors substrate–1 (IRS-1).
Journal ArticleDOI
A central role for JNK in obesity and insulin resistance
Jiro Hirosumi,Gurol Tuncman,Lufen Chang,Cem Z. Görgün,K. Teoman Uysal,Kazuhisa Maeda,Michael Karin,Gökhan S. Hotamisligil +7 more
TL;DR: It is shown that JNK activity is abnormally elevated in obesity and an absence of JNK1 results in decreased adiposity, significantly improved insulin sensitivity and enhanced insulin receptor signalling capacity in two different models of mouse obesity.
Journal ArticleDOI
Treatment of diabetes and atherosclerosis by inhibiting fatty-acid-binding protein aP2
Masato Furuhashi,Gurol Tuncman,Cem Z. Görgün,Liza Makowski,Liza Makowski,Genichi Atsumi,Genichi Atsumi,Eric Vaillancourt,Keita Kono,Vladimir R. Babaev,Sergio Fazio,MacRae F. Linton,Richard B. Sulsky,Jeffrey A. Robl,Rex A. Parker,Gökhan S. Hotamisligil +15 more
TL;DR: It is demonstrated that an orally active small-molecule inhibitor of aP2 is an effective therapeutic agent against severe atherosclerosis and type 2 diabetes in mouse models and can lead to a new class of powerful therapeutic agents to prevent and treat metabolic diseases such as type 2 diabetes and atheros sclerosis.
Journal ArticleDOI
Double-Stranded RNA-Dependent Protein Kinase Links Pathogen Sensing with Stress and Metabolic Homeostasis
Takahisa Nakamura,Masato Furuhashi,Ping Li,Haiming Cao,Gurol Tuncman,Nahum Sonenberg,Cem Z. Görgün,Gökhan S. Hotamisligil,Gökhan S. Hotamisligil +8 more
TL;DR: Evidence is provided that double-stranded RNA-dependent protein kinase (PKR) can respond to nutrient signals as well as endoplasmic reticulum (ER) stress and coordinate the activity of other critical inflammatory kinases to regulate insulin action and metabolism.
Journal ArticleDOI
Functional in vivo interactions between JNK1 and JNK2 isoforms in obesity and insulin resistance
Gurol Tuncman,Jiro Hirosumi,Giovanni Solinas,Lufen Chang,Michael Karin,Gökhan S. Hotamisligil +5 more
TL;DR: Interestingly, a higher-than-normal level of JNK activation is observed in Jnk2(-/-) mice, particularly in the liver, indicating an interaction between the isoforms that might have masked the metabolic activity of J NK2 in isolated mutant mice.