A
Ann-Hwee Lee
Researcher at Cornell University
Publications - 63
Citations - 17739
Ann-Hwee Lee is an academic researcher from Cornell University. The author has contributed to research in topics: Unfolded protein response & Endoplasmic reticulum. The author has an hindex of 40, co-authored 63 publications receiving 16043 citations. Previous affiliations of Ann-Hwee Lee include Harvard University & Regeneron.
Papers
More filters
Journal ArticleDOI
Endoplasmic Reticulum Stress Links Obesity, Insulin Action, and Type 2 Diabetes
Umut Ozcan,Qiong Cao,Erkan Yilmaz,Ann-Hwee Lee,Neal N. Iwakoshi,Esra Özdelen,Gurol Tuncman,Cem Z. Görgün,Laurie H. Glimcher,Gökhan S. Hotamisligil +9 more
TL;DR: It is shown that obesity causes endoplasmic reticulum (ER) stress, which leads to suppression of insulin receptor signaling through hyperactivation of c-Jun N-terminal kinase (JNK) and subsequent serine phosphorylation of insulin receptors substrate–1 (IRS-1).
Journal ArticleDOI
XBP-1 Regulates a Subset of Endoplasmic Reticulum Resident Chaperone Genes in the Unfolded Protein Response
TL;DR: It is suggested that the IRE1/XBP-1 pathway is required for efficient protein folding, maturation, and degradation in the ER and imply the existence of subsets of UPR target genes as defined by their dependence on XBP- 1.
Journal ArticleDOI
XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease
Arthur Kaser,Ann-Hwee Lee,Andre Franke,Jonathan N. Glickman,Sebastian Zeissig,Herbert Tilg,Edward E. S. Nieuwenhuis,Darren E. Higgins,Stefan Schreiber,Laurie H. Glimcher,Richard S. Blumberg +10 more
TL;DR: It is reported that XBP1 deletion in intestinal epithelial cells (IECs) results in spontaneous enteritis and increased susceptibility to induced colitis secondary to both Paneth cell dysfunction and an epithelium that is overly reactive to inducers of IBD such as bacterial products (flagellin) and TNFalpha.
Journal ArticleDOI
XBP1, downstream of Blimp-1, expands the secretory apparatus and other organelles, and increases protein synthesis in plasma cell differentiation.
Arthur L. Shaffer,Miriam Shapiro-Shelef,Neal N. Iwakoshi,Ann-Hwee Lee,Shu-Bing Qian,Hong Zhao,Xin Yu,Liming Yang,Bruce K. Tan,Andreas Rosenwald,Elaine M. Hurt,Emmanuel Petroulakis,Nahum Sonenberg,Jonathan W. Yewdell,Kathryn Calame,Laurie H. Glimcher,Louis M. Staudt +16 more
TL;DR: XBP1 coordinates diverse changes in cellular structure and function resulting in the characteristic phenotype of professional secretory cells, and upregulates genes encoding many secretory pathway components.
Journal ArticleDOI
Regulation of hepatic lipogenesis by the transcription factor XBP1
TL;DR: It is found that the transcription factor XBP1, a key regulator of the unfolded protein response, is required for the unrelated function of normal fatty acid synthesis in the liver.