J
Jessica Dausman
Researcher at Massachusetts Institute of Technology
Publications - 14
Citations - 5642
Jessica Dausman is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Transgene & Gene. The author has an hindex of 14, co-authored 14 publications receiving 5472 citations.
Papers
More filters
Journal ArticleDOI
Induction of tumors in mice by genomic hypomethylation.
François Gaudet,J. Graeme Hodgson,Amir Eden,Laurie Jackson-Grusby,Jessica Dausman,Joe W. Gray,Heinrich Leonhardt,Rudolf Jaenisch +7 more
TL;DR: Results indicate that DNA hypomethylation plays a causal role in tumor formation, possibly by promoting chromosomal instability.
Journal ArticleDOI
Direct Reprogramming of Terminally Differentiated Mature B Lymphocytes to Pluripotency
Jacob H. Hanna,Styliani Markoulaki,Patrick Schorderet,Bryce W. Carey,Caroline Beard,Marius Wernig,Menno P. Creyghton,Eveline J. Steine,John P. Cassady,Ruth K. Foreman,Christopher J. Lengner,Jessica Dausman,Rudolf Jaenisch +12 more
TL;DR: This study provides definite proof for the direct nuclear reprogramming of terminally differentiated adult cells to pluripotency through transgenic and inducible expression of transcription factors.
Journal ArticleDOI
Loss of genomic methylation causes p53-dependent apoptosis and epigenetic deregulation.
Laurie Jackson-Grusby,Caroline Beard,Richard Possemato,Matthew Tudor,Douglas Fambrough,Györgyi Csankovszki,Jessica Dausman,Peggy Lee,Christopher B. Wilson,Eric S. Lander,Rudolf Jaenisch +10 more
TL;DR: The results demonstrate that loss of Dnmt1 causes cell-type–specific changes in gene expression that impinge on several pathways, including expression of imprinted genes, cell-cycle control, growth factor/receptor signal transduction and mobilization of retroelements.
Journal ArticleDOI
Xist-deficient mice are defective in dosage compensation but not spermatogenesis.
TL;DR: The results indicate that the Xist RNA is required for female dosage compensation but plays no role in spermatogenesis.
Journal ArticleDOI
Generation of mice from wild-type and targeted ES cells by nuclear cloning
William M. Rideout,Teruhiko Wakayama,Anton Wutz,Kevin Eggan,Laurie Jackson-Grusby,Jessica Dausman,Ryuzo Yanagimachi,Rudolf Jaenisch +7 more
TL;DR: This work aims to provide a clear picture of the role of apoptosis in women’s sexual development and aims to clarify the roles of “cell reprograming” and “reconcretization” in this disease.