Showing papers in "Steroids in 2012"

TL;DR: In vitro studies support the contention that inflammation directly stimulates the polycystic ovary to produce androgens, and markers of oxidative stress and inflammation are highly correlated with circulating androgens in PCOS.

TL;DR: The role of aromatase in different tissues under normal physiological conditions and its contribution to the development of some oestrogen-related pathologies are reviewed.

TL;DR: This article covers the microbial transformation of sterols, steroidal hormones and some new types of steroids known as bufadienolides, which covers the literature from 1994 to 2011.

TL;DR: HA may adversely affect LH pulse regulation during pubertal maturation leading to persistent HA and the development of PCOS, potentially related to normally increasing levels of testosterone during puberty.

TL;DR: A high carbohydrate and protein breakfast may prevent weight regain by reducing diet-induced compensatory changes in hunger, cravings and ghrelin suppression.

TL;DR: There is no convincing evidence for biosynthesis of vertebrate steroids by mollusks, and the 'mollusk' genome does not contain the genes for key enzymes that are necessary to transform cholesterol in progressive steps into vertebrate-type steroids.

TL;DR: The current knowledge and questions about GPER-dependent signaling and function are reviewed, and controversies that have complicated the understanding of GPER are discussed.

TL;DR: Data underscore the need to screen all women with PCOS for mood and anxiety disorders and adequately treat women who are diagnosed with these conditions and insufficient data examining the risk of other anxiety disorders.

TL;DR: The similarities and differences from glandular androgen synthesis that have already emerged provide important clues to designing the next generation of treatments for this common and devastating disease.

TL;DR: Among the screened compounds, 2i, 2n and 4f showed significant inhibitory activity against all the three human cell lines and their biological evaluation as potential anticancer agents are reported.

TL;DR: New results demonstrate the capability of T(3) or T(4) to induce in the short time range important responses related to the immune function, such as reactive oxygen species production and cell migration in THP-1 monocytes.

TL;DR: Tests to augment tissue GC sensitivity are predicted to permit safe and effective use of low-dose GC therapy in inflammatory disease, and are discussed here.

TL;DR: Detailed chemical investigation on the stems and leaves of Paris polyphylla var.

TL;DR: The variable response among different assays for 25(OH)D metabolites impedes the use of uniform cut-off values for defining vitamin D status and indicates the need towards further standardizing assay measurement.

TL;DR: Life-long apolipoprotein lipid metabolic dysfunction in women with PCOS exaggerates the risk for cardiovascular disease (CVD) with aging and diet and exercise interventions followed by selective lipid lowering medications are encouraged to normalize the dyslipidemia.

TL;DR: Cell culture and in vivo data in mice strongly suggest that calcitriol and dietary vitamin D would play a beneficial role in the prevention and/or treatment of ER+BCa in women.

TL;DR: The ability of two diet-derived flavonoids and of the synthetic food-contaminant bisphenol A to modulate specifically ER extra-nuclear signalling pathways will be reported.

TL;DR: This work overviews the literature examining a role of androgens in the etiology of breast cancer and concludes that expression of the androgen receptor is a positive prognostic factor.

TL;DR: The alkylation of six cysteine residues showed that IKKβ is a potential target for the anti-inflammatory activity of physalin A, which indicated that the inducible nitric oxide synthase (iNOS) assay was used to demonstrate that the dichloromethane extract of Physalis alkekengi var.

TL;DR: This review addresses the gaps in knowledge in ERβ research as it pertains to BCa regarding the following questions: is ERβ a tumor suppressor inBCa?

TL;DR: The cytotoxicity of the newly synthesized heterocyclic steroids against three human tumor cell lines namely breast adenocarcinoma, non-small cell lung cancer and CNS cancer were studied and some of tested compounds were found to exhibit much higher inhibitory effects towards the three tumor cell Lines than the reference drug, doxorubicin.

TL;DR: The genetics of NCCAH is discussed, along with its variable phenotypic expression, and the clinical course in untreated patients, which includes rapid early childhood growth, advanced skeletal age, premature adrenarche, acne, impaired reproductive function in both sexes and hirsutism as well as menstrual disorders in females are reviewed.

TL;DR: The preparation of A-ring and D-ring fused steroidal quinolines is described from one-pot reaction of steroidal β-bromovinylaldehydes and arylamines in solvent-free and catalyst-free condition under microwave irradiation to show promising in vitro activity and antimicrobial activities.

TL;DR: GPR30, early in 2011, showed its involvement in rapid aldosterone action, and major pharmacological aspects of this action are compatible with the landmark deviations from MR pharmacology mentioned above, suggesting GPR30 may be a receptor candidate for nongenomic ald testosterone action.

TL;DR: This review provides a uniform approach to the naming of 26-hydroxylated sterols for those of current interest and for those on the horizon such as oxysterols of lanosterol that retain the unsaturation at C-24 and C-25 such as (E)-26-Hydroxylanosterol.

TL;DR: As in chicks and rats, intestinal cells from adult male mice lost the ability to respond to 1,25D(3) with enhanced phosphate uptake, whereas in female mice, uptake in cells from adults was greater than that observed in young mice.

TL;DR: The structures of these compounds were elucidated on the basis of extensive spectroscopic analyses (1D and 2D NMR, IR, HR-MS) and chemical methods.

TL;DR: The tumor suppressive capability of estrogen receptor β makes it a promising drug target for the treatment and prevention of prostate cancer and different aspects of estrogen receptors signaling and prostate cancer are focused on.

TL;DR: Xenoestrogens, like physiologic estrogens, can evoke downstream kinase signaling involving selective interactions of ERα with G(αi) and caveolin I, but with some different characteristics, which could explain their disruptive actions.

TL;DR: It is demonstrated that ZS is an effective natural agent for cancer therapy, which may be mediated, in part, by induction of apoptosis, and DZW's potential as an anticancer agent is worth being further investigated.