H
H. Le Marec
Researcher at University of Nantes
Publications - 17
Citations - 1634
H. Le Marec is an academic researcher from University of Nantes. The author has contributed to research in topics: Brugada syndrome & Sudden death. The author has an hindex of 9, co-authored 17 publications receiving 1512 citations. Previous affiliations of H. Le Marec include Centre national de la recherche scientifique & French Institute of Health and Medical Research.
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Journal ArticleDOI
Long-Term Prognosis of Patients Diagnosed With Brugada Syndrome Results From the FINGER Brugada Syndrome Registry
Vincent Probst,Christian Veltmann,Lars Eckardt,Paola G. Meregalli,Fiorenzo Gaita,Hanno L. Tan,Dominique Babuty,Frederic Sacher,Carla Giustetto,Eric Schulze-Bahr,Martin Borggrefe,M. Haissaguerre,Philippe Mabo,H. Le Marec,Christian Wolpert,Arthur A.M. Wilde +15 more
TL;DR: In the largest series of Brugada syndrome patients thus far, event rates in asymptomatic patients were low and gender, familial history of SCD, inducibility of ventricular tachyarrhythmias during electrophysiological study, and the presence of an SCN5A mutation were not predictive of arrhythmic events.
Journal ArticleDOI
Cardiac conduction defects associate with mutations in SCN5A.
Jean-Jacques Schott,C Alshinawi,Florence Kyndt,Vincent Probst,Theo M. Hoorntje,MM Hulsbeek,Arthur A.M. Wilde,Denis Escande,Marcel M.A.M. Mannens,H. Le Marec +9 more
Journal ArticleDOI
An evaluation of automaticity and triggered activity in the canine heart one to four days after myocardial infarction.
TL;DR: Although delayed afterdepolarizations occur at 24 hr after infarction in the standard Harris preparation, they are most readily seen as an accompaniment of hyperpolarization, pacing, or lowering of bath temperature.
Journal ArticleDOI
Valvular dystrophy associated filamin A mutations reveal a new role of its first repeats in small-GTPase regulation
Delphine Duval,Aurélie Lardeux,T. Le Tourneau,Russell A. Norris,Roger R. Markwald,V. Sauzeau,Vincent Probst,H. Le Marec,Ross L. Levine,Jean-Jacques Schott,Jean Mérot +10 more
TL;DR: A new role is ascribed to the N-terminal repeats of FlnA in Small GTPases regulation and a conceptual framework for the role of FlNA mutations in cardiac valve diseases centered around signaling molecules regulating cellular actin cytoskeleton in response to mechanical stress is supported.
Journal ArticleDOI
The effects of doxorubicin on ventricular tachycardia.
TL;DR: Results indicate that agents having high selectivity for specific arrhythmogenic mechanisms can be useful adjuncts in discriminating among the mechanisms responsible for arrh rhythmias in intact animals.