J
Jean Mérot
Researcher at French Institute of Health and Medical Research
Publications - 56
Citations - 2262
Jean Mérot is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: FLNA & Mitral valve prolapse. The author has an hindex of 27, co-authored 51 publications receiving 1986 citations. Previous affiliations of Jean Mérot include Centre national de la recherche scientifique & University of Nantes.
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Journal ArticleDOI
Mitral valve disease—morphology and mechanisms
Robert A. Levine,Albert Hagège,Daniel P. Judge,Muralidhar Padala,Jacob P. Dal-Bianco,Elena Aikawa,Jonathan Beaudoin,Joyce Bischoff,Nabila Bouatia-Naji,Patrick Bruneval,Jonathan T. Butcher,Alain Carpentier,Miguel Chaput,Adrian H. Chester,Catherine Clusel,Francesca N. Delling,Harry C. Dietz,Christian Dina,Ronen Durst,Leticia Fernández-Friera,Mark D. Handschumacher,Morten O. Jensen,Xavier Jeunemaitre,Hervé Le Marec,Thierry Le Tourneau,Roger R. Markwald,Jean Mérot,Emmanuel Messas,David P. Milan,Tui Neri,Russell A. Norris,David S. Peal,Maelle Perrocheau,Vincent Probst,Michael Pucéat,Nadia Rosenthal,Jorge Solis,Jean-Jacques Schott,Ehud Schwammenthal,Susan A. Slaugenhaupt,Jae-Kwan Song,Magdi H. Yacoub +41 more
TL;DR: The approach, which bridges clinicians and basic scientists, enables the correlation of observed disease with cellular and molecular mechanisms, leading to the discovery of new opportunities for improving the natural history of mitral valve disease.
Journal ArticleDOI
Polarized trafficking and surface expression of the AQP4 water channel are coordinated by serial and regulated interactions with different clathrin-adaptor complexes.
Ricardo Madrid,Sophie Le Maout,Marie-Bénédicte Barrault,Katy Janvier,Serge Benichou,Jean Mérot +5 more
TL;DR: It is shown that two independent C‐terminal signals determine AQP4 basolateral membrane targeting in epithelial MDCK cells, and stress‐induced kinase casein kinase (CK)II phosphorylates the Ser276 immediately preceding the tyrosine motif, increasing AQp4–μ3A interaction and enhancing AQP 4–lysosomal targeting and degradation.
Journal ArticleDOI
Multifocal Ectopic Purkinje-Related Premature Contractions A New SCN5A-Related Cardiac Channelopathy
Gabriel Laurent,Samuel Saal,Mohamed Yassine Amarouch,Delphine M. Béziau,Roos F. Marsman,Laurence Faivre,Julien Barc,Christian Dina,Géraldine Bertaux,Olivier Barthez,Christel Thauvin-Robinet,Philippe Charron,Véronique Fressart,Alice Maltret,Elisabeth Villain,Estelle Baron,Jean Mérot,Rodolphe Turpault,Yves Coudière,Flavien Charpentier,Jean-Jacques Schott,Gildas Loussouarn,Arthur A.M. Wilde,Jean-Eric Wolf,Isabelle Baró,Florence Kyndt,Vincent Probst +26 more
TL;DR: A new SCN5A-related cardiac syndrome, MEPPC, was identified, which leads to a gain of function of the sodium channel responsible for hyperexcitability of the fascicular-Purkinje system.
Journal ArticleDOI
Impaired KCNQ1–KCNE1 and Phosphatidylinositol-4,5-Bisphosphate Interaction Underlies the Long QT Syndrome
Kyu-Ho Park,Julien Piron,Shehrazade Dahimène,Jean Mérot,Isabelle Baró,Denis Escande,Gildas Loussouarn +6 more
TL;DR: It is shown that PIP2 affinity is reduced in three KCNQ1 mutant channels (R243H, R539W, and R555C) associated with the long QT syndrome, and the data suggest that a reduced PIP 2 affinity of KCNZ1 mutants can lead to the longQT syndrome.
Journal ArticleDOI
Kv7.1 (KCNQ1) properties and channelopathies
David Peroz,Nicolas Rodriguez,Nicolas Rodriguez,Nicolas Rodriguez,Frank S. Choveau,Frank S. Choveau,Frank S. Choveau,Isabelle Baró,Isabelle Baró,Isabelle Baró,Jean Mérot,Jean Mérot,Jean Mérot,Gildas Loussouarn,Gildas Loussouarn,Gildas Loussouarn +15 more
TL;DR: A considerable amount of work remains to be done to get a clear picture of the molecular mechanisms responsible for the pathogenesis related to each mutation of KCNQ1, and the present review gives three examples of recent studies towards this goal and illustrates the diversity of the Molecular mechanisms involved.