抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1（PfPMP1）与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员，通过启动转录不同的var基因变异体为抗原变异提供了分子基础。

疟原虫var基因转换速率变化导致抗原变异[英]／Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A

Graphene and related two-dimensional crystals and hybrid systems showcase several key properties that can address emerging energy needs, in particular for the ever growing market of portable and wearable energy conversion and storage devices. Graphene's flexibility, large surface area, and chemical stability, combined with its excellent electrical and thermal conductivity, make it promising as a catalyst in fuel and dye-sensitized solar cells. Chemically functionalized graphene can also improve storage and diffusion of ionic species and electric charge in batteries and supercapacitors. Two-dimensional crystals provide optoelectronic and photocatalytic properties complementing those of graphene, enabling the realization of ultrathin-film photovoltaic devices or systems for hydrogen production. Here, we review the use of graphene and related materials for energy conversion and storage, outlining the roadmap for future applications.

Graphene, related two-dimensional crystals, and hybrid systems for energy conversion and storage

We present the science and technology roadmap for graphene, related two-dimensional crystals, and hybrid systems, targeting an evolution in technology, that might lead to impacts and benefits reaching into most areas of society. This roadmap was developed within the framework of the European Graphene Flagship and outlines the main targets and research areas as best understood at the start of this ambitious project. We provide an overview of the key aspects of graphene and related materials (GRMs), ranging from fundamental research challenges to a variety of applications in a large number of sectors, highlighting the steps necessary to take GRMs from a state of raw potential to a point where they might revolutionize multiple industries. We also define an extensive list of acronyms in an effort to standardize the nomenclature in this emerging field.

/pdf/science-and-technology-roadmap-for-graphene-related-two-4q9m7czlkc.pdf

Science and technology roadmap for graphene, related two-dimensional crystals, and hybrid systems

The compelling demand for higher performance and lower power consumption in electronic systems is the main driving force of the electronics industry's quest for devices and/or architectures based on new materials. Here, we provide a review of electronic devices based on two-dimensional materials, outlining their potential as a technological option beyond scaled complementary metal-oxide-semiconductor switches. We focus on the performance limits and advantages of these materials and associated technologies, when exploited for both digital and analog applications, focusing on the main figures of merit needed to meet industry requirements. We also discuss the use of two-dimensional materials as an enabling factor for flexible electronics and provide our perspectives on future developments.

Electronics based on two-dimensional materials

Gold nanorods have been receiving extensive attention owing to their extremely attractive applications in biomedical technologies, plasmon-enhanced spectroscopies, and optical and optoelectronic devices. The growth methods and plasmonic properties of Au nanorods have therefore been intensively studied. In this review, we present a comprehensive overview of the flourishing field of Au nanorods in the past five years. We will focus mainly on the approaches for the growth, shape and size tuning, functionalization, and assembly of Au nanorods, as well as the methods for the preparation of their hybrid structures. The plasmonic properties and the associated applications of Au nanorods will also be discussed in detail.

Gold nanorods and their plasmonic properties

The growth of high-quality single crystals of graphene by chemical vapor deposition on copper (Cu) has not always achieved control over domain size and morphology, and the results vary from lab to lab under presumably similar growth conditions. We discovered that oxygen (O) on the Cu surface substantially decreased the graphene nucleation density by passivating Cu surface active sites. Control of surface O enabled repeatable growth of centimeter-scale single-crystal graphene domains. Oxygen also accelerated graphene domain growth and shifted the growth kinetics from edge-attachment–limited to diffusion-limited. Correspondingly, the compact graphene domain shapes became dendritic. The electrical quality of the graphene films was equivalent to that of mechanically exfoliated graphene, in spite of being grown in the presence of O.

http://utw10193.utweb.utexas.edu/Archive/RuoffsPDFs/362.pdf

The Role of Surface Oxygen in the Growth of Large Single-Crystal Graphene on Copper

Anisotropic Growth of Titania onto Various Gold Nanostructures: Synthesis, Theoretical Understanding, and Optimization for Catalysis

Nanoscale pattern formation on surfaces by ion beam sputtering is driven by the competition between the erosion and the diffusion processes. In alloys, these processes are component-dependent. We present a kinetic Monte Carlo model for sputtering of alloy surfaces which exhibits morphological ripples and compositional patterns. The evolution of the ripple amplitude shows a crossover from an early stage exponential growth to a later stage power-law growth. We also present a nonlinear dynamic model which shows both the crossover and the surface patterns, confirming the importance of nonlinear terms in understanding the dynamics of alloy sputtering.

Pattern formation and nonlinear evolution in alloy surfaces by ion-beam sputtering

Following our previous work on the united-atom simulation on octacosane (C28H58) (Dai et al., Phys. Chem. Chem. Phys., 2021, 23, 21262-21271), we developed a coarse grain scheme (CG10), which is able to reproduce the pivotal phase characteristics of octacosane with highly improved computational efficiency. The CG10 octacosane chain was composed of 10 consecutive beads, maintaining the fundamental zigzag chain morphology. When the potential functions were set up and the coefficients were parameterized, our CG10 models yielded solid phase diagrams and transitions during an annealing process. We also detected the melting point by various means: direct observation, bond order, density tracking, and an enthalpy plot. Furthermore, our CG10 successfully reproduced the liquid density with only 2% underestimation, indicating its applicability across the solid and liquid phases. Therefore, with the ability to reproduce critical structure and property characteristics, our CG10 scheme provides an effective means of numerically modelling octacosane with highly improved computational efficiency.

H. Ramanarayan

Papers

The Role of Surface Oxygen in the Growth of Large Single-Crystal Graphene on Copper

Anisotropic Growth of Titania onto Various Gold Nanostructures: Synthesis, Theoretical Understanding, and Optimization for Catalysis

Pattern formation and nonlinear evolution in alloy surfaces by ion-beam sputtering

Molecular simulation of linear octacosane via a CG10 coarse grain scheme.