S
Sophia Hsin-Jung Li
Researcher at Princeton University
Publications - 25
Citations - 2079
Sophia Hsin-Jung Li is an academic researcher from Princeton University. The author has contributed to research in topics: Translation (biology) & Protein biosynthesis. The author has an hindex of 11, co-authored 23 publications receiving 1548 citations. Previous affiliations of Sophia Hsin-Jung Li include Zhejiang University of Science and Technology & Massachusetts Institute of Technology.
Papers
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Journal ArticleDOI
Paracrine and autocrine signals induce and maintain mesenchymal and stem cell states in the breast.
Christina Scheel,Elinor Ng Eaton,Sophia Hsin-Jung Li,Christine L. Chaffer,Ferenc Reinhardt,Kong Jie Kah,George W. Bell,Wenjun Guo,Jeffrey S. Rubin,Andrea L. Richardson,Robert A. Weinberg +10 more
TL;DR: In this article, the authors describe three signaling pathways, involving transforming growth factor (TGF)-β and canonical and noncanonical Wnt signaling, that collaborate to induce activation of the EMT program and thereafter function in an autocrine fashion to maintain the resulting mesenchymal state.
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Subfemtotesla scalar atomic magnetometry using multipass cells.
TL;DR: A pump-probe measurement scheme to suppress spin-exchange relaxation and two probe pulses to find the spin precession zero crossing times is used and a magnetic field sensitivity of 0.54 fT/Hz(1/2), which improves by an order of magnitude the best scalar magnetometer sensitivity.
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Mitochondrial translation requires folate-dependent tRNA methylation
Raphael J. Morscher,Gregory S. Ducker,Sophia Hsin-Jung Li,Johannes A. Mayer,Zemer Gitai,Wolfgang Sperl,Joshua D. Rabinowitz +6 more
TL;DR: It is shown that loss of the catalytic activity of the mitochondrial folate enzyme serine hydroxymethyltransferase 2 (SHMT2), but not of other folate enzymes, leads to defective oxidative phosphorylation in human cells due to impaired mitochondrial translation.
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Human SHMT inhibitors reveal defective glycine import as a targetable metabolic vulnerability of diffuse large B-cell lymphoma
Gregory S. Ducker,Jonathan M. Ghergurovich,Nello Mainolfi,Vipin Suri,Stephanie K. Jeong,Sophia Hsin-Jung Li,Adam Friedman,Mark Manfredi,Zemer Gitai,Hahn Kim,Joshua D. Rabinowitz +10 more
TL;DR: It is shown genetically that dual SHMT1/2 knockout blocks HCT-116 colon cancer tumor xenograft formation and defective glycine import is a targetable metabolic deficiency of DLBCL.
Journal ArticleDOI
A Dual-Mechanism Antibiotic Kills Gram-Negative Bacteria and Avoids Drug Resistance.
James K. Martin,Joseph P. Sheehan,Benjamin P. Bratton,Gabriel M. Moore,André Mateus,Sophia Hsin-Jung Li,Hahn Kim,Joshua D. Rabinowitz,Athanasios Typas,Mikhail M. Savitski,Maxwell Z. Wilson,Maxwell Z. Wilson,Zemer Gitai +12 more
TL;DR: A compound is characterized that kills both Gram-negative and Gram-positive bacteria through a unique dual-targeting mechanism of action (MoA) with undetectably low resistance frequencies, and suggests that combining multiple MoAs onto a single chemical scaffold may be an underappreciated approach to targeting challenging bacterial pathogens.