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Anli Zhang
Researcher at University of Texas Southwestern Medical Center
Publications - 31
Citations - 1693
Anli Zhang is an academic researcher from University of Texas Southwestern Medical Center. The author has contributed to research in topics: Immunotherapy & Cytotoxic T cell. The author has an hindex of 14, co-authored 24 publications receiving 1024 citations. Previous affiliations of Anli Zhang include Fudan University & Fudan University Shanghai Medical College.
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Journal ArticleDOI
Follicular CXCR5-expressing CD8 + T cells curtail chronic viral infection
Ran He,Shiyue Hou,Cheng Liu,Anli Zhang,Qiang Bai,Miao Han,Yu Yang,Gang Wei,Ting Shen,Xinxin Yang,Lifan Xu,Xiangyu Chen,Yaxing Hao,Pengcheng Wang,Chuhong Zhu,Juanjuan Ou,Houjie Liang,Ting Ni,Xiaoyan Zhang,Xinyuan Zhou,Kai Deng,Yaokai Chen,Yadong Luo,Jianqing Xu,Hai Qi,Yuzhang Wu,Lilin Ye +26 more
TL;DR: A subset of exhausted CD8+ T cells expressing the chemokine receptor CXCR5 has a critical role in the control of viral replication in mice that were chronically infected with lymphocytic choriomeningitis virus (LCMV).
Journal ArticleDOI
Early hypercytokinemia is associated with interferon-induced transmembrane protein-3 dysfunction and predictive of fatal H7N9 infection
Zhongfang Wang,Anli Zhang,Yanmin Wan,Xinian Liu,Chao Qiu,Xiuhong Xi,Yanqin Ren,Jing Wang,Yuan Dong,Meijuan Bao,Liangzhu Li,Mingzhe Zhou,Songhua Yuan,Jun Sun,Zhaoqin Zhu,Liang Chen,Qingsheng Li,Zhiyong Zhang,Xiaoyan Zhang,Xiaoyan Zhang,Shuihua Lu,Peter C. Doherty,Peter C. Doherty,Katherine Kedzierska,Jianqing Xu,Jianqing Xu +25 more
TL;DR: The present analysis provides reported data on the H7N9 influenza-induced “cytokine storm” at the site of infection in humans and identifies the rs12252-C genotype that compromises IFITM3 function as a primary genetic correlate of severe H7n9 pneumonia.
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Hybrid cellular membrane nanovesicles amplify macrophage immune responses against cancer recurrence and metastasis
Lang Rao,Lei Wu,Zhida Liu,Rui Tian,Rui Tian,Guocan Yu,Zijian Zhou,Kuikun Yang,Hong Gang Xiong,Anli Zhang,Guang Tao Yu,Wenjing Sun,Han Xu,Jingya Guo,Andrew Li,Hongmin Chen,Z.J. Sun,Yang Xin Fu,Xiaoyuan Chen +18 more
TL;DR: The hNVs block CD47-SIRPα signaling axis while promoting M2-to-M1 repolarization within tumor microenvironment, significantly preventing both local recurrence and distant metastasis in malignant melanoma models.
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DNA Sensing in Mismatch Repair-Deficient Tumor Cells Is Essential for Anti-tumor Immunity.
Changzheng Lu,Junhong Guan,Steve Lu,Qihuang Jin,Benoit Rousseau,Tianshi Lu,Dennis Stephens,Hongyi Zhang,Jiankun Zhu,Mingming Yang,Zhenhua Ren,Yong Liang,Zhida Liu,Chuanhui Han,Longchao Liu,Xuezhi Cao,Anli Zhang,Jian Qiao,Kimberly Batten,Mingyi Chen,Diego H. Castrillon,Tao Wang,Bo Li,Luis A. Diaz,Guo Min Li,Yang Xin Fu +25 more
TL;DR: Using tumor models defective in the MMR gene Mlh1, it is shown that dMLH1 tumor cells accumulate cytosolic DNA and produce IFN-β in a cGAS-STING-dependent manner, which renders d MLH1 tumors slowly progressive and highly sensitive to checkpoint blockade.
Journal ArticleDOI
The Upregulation of LAG-3 on T Cells Defines a Subpopulation with Functional Exhaustion and Correlates with Disease Progression in HIV-Infected Subjects
Xiaoling Tian,Anli Zhang,Chao Qiu,Wei Wang,Yu Yang,Chenli Qiu,Aiping Liu,Lingyan Zhu,Songhua Yuan,Huiliang Hu,Wanhai Wang,Qiang Wei,Xiaoyan Zhang,Xiaoyan Zhang,Jianqing Xu,Jianqing Xu +15 more
TL;DR: It is revealed that LAG-3 on T cells delivers an inhibitory signal to downregulate T cell functionality, thereby playing an immunoregulatory role during persistent HIV-1 infection and providing an important target for enhancing immune reconstitution in HIV-infected patients.