J
Jennifer L. Cannons
Researcher at National Institutes of Health
Publications - 44
Citations - 6890
Jennifer L. Cannons is an academic researcher from National Institutes of Health. The author has contributed to research in topics: T cell & Germinal center. The author has an hindex of 28, co-authored 41 publications receiving 6323 citations. Previous affiliations of Jennifer L. Cannons include Uniformed Services University of the Health Sciences.
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Journal ArticleDOI
A Mosaic Activating Mutation in AKT1 Associated with the Proteus Syndrome
Marjorie J. Lindhurst,Julie C Sapp,Jamie K. Teer,Jennifer J. Johnston,Erin M Finn,Kathryn F. Peters,Joyce T. Turner,Jennifer L. Cannons,David P. Bick,Laurel C Blakemore,Catherine Blumhorst,Knut Brockmann,Peter Calder,Natasha Cherman,Matthew A. Deardorff,David B. Everman,Gretchen Golas,Robert M. Greenstein,B. Maya Kato,Kim M. Keppler-Noreuil,Sergei A. Kuznetsov,Richard T. Miyamoto,Kurt D. Newman,David Ng,Kevin O'Brien,Steven S. Rothenberg,Douglas J. Schwartzentruber,Virender Singhal,Roberto Tirabosco,Joseph Upton,Shlomo Wientroub,Elaine H. Zackai,Kimberly Hoag,Tracey Whitewood-Neal,Pamela Gehron Robey,Pamela L. Schwartzberg,Thomas N. Darling,Laura L. Tosi,James C. Mullikin,Leslie G. Biesecker +39 more
TL;DR: In this article, exome sequencing of DNA from biopsy samples obtained from patients with the Proteus syndrome and compared the resultant DNA sequences with those of unaffected tissues obtained from the same patients were performed.
Journal ArticleDOI
SAP-controlled T-B cell interactions underlie germinal centre formation.
TL;DR: It is shown that SAP deficiency selectively impairs the ability of CD4+ T cells to stably interact with cognate B cells but not antigen-presenting dendritic cells, which results in a failure of antigen-specific B cells to receive adequate levels of contact-dependent T-cell help to expand normally.
Journal ArticleDOI
Follicular helper T cells are required for systemic autoimmunity.
Michelle A. Linterman,Robert J. Rigby,Raphael Wong,Di Yu,Robert Brink,Jennifer L. Cannons,Pamela L. Schwartzberg,Matthew C. Cook,Matthew C. Cook,Giles Walters,Giles Walters,Carola G. Vinuesa +11 more
TL;DR: TFH dysfunction within GCs and aberrant positive selection as a pathway to systemic autoimmunity are identified and TFH dysfunction inside GCs is identified and acts autonomously to cause accumulation of TFH cells.
Journal ArticleDOI
Dominant-activating germline mutations in the gene encoding the PI(3)K catalytic subunit p110δ result in T cell senescence and human immunodeficiency
Carrie L. Lucas,Hye Sun Kuehn,Fang Zhao,Julie E. Niemela,Elissa K. Deenick,Umaimainthan Palendira,Danielle T. Avery,Leen Moens,Jennifer L. Cannons,Matthew Biancalana,Jennifer Stoddard,Weiming Ouyang,David M. Frucht,V. Koneti Rao,T. Prescott Atkinson,Anahita Agharahimi,Ashleigh A. Hussey,Les R. Folio,Kenneth N. Olivier,Thomas A. Fleisher,Stefania Pittaluga,Steven M. Holland,Jeffrey I. Cohen,Joao Bosco Oliveira,Stuart G. Tangye,Pamela L. Schwartzberg,Michael J. Lenardo,Gulbu Uzel +27 more
TL;DR: T cells from patients with heterozygous for three different germline, gain-of-function mutations in PIK3CD exhibited increased phosphorylation of the kinase Akt and hyperactivation of the metabolic checkpoint kinase mTOR, enhanced glucose uptake and terminal effector differentiation in vitro.
Journal ArticleDOI
SLAM Family Receptors and SAP Adaptors in Immunity
TL;DR: Recent findings on the roles of SLAM family receptors and the SAP family of adaptors are covered, with a focus on their regulation of the pathways involved in the pathogenesis of XLP and other immune disorders.