H
Hai-Yan Tian
Researcher at Jinan University
Publications - 78
Citations - 1252
Hai-Yan Tian is an academic researcher from Jinan University. The author has contributed to research in topics: Medicine & Bufadienolide. The author has an hindex of 18, co-authored 69 publications receiving 996 citations. Previous affiliations of Hai-Yan Tian include China Pharmaceutical University & Chinese Ministry of Education.
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Journal ArticleDOI
Arenobufagin, a natural bufadienolide from toad venom, induces apoptosis and autophagy in human hepatocellular carcinoma cells through inhibition of PI3K/Akt/mTOR pathway
Dong-Mei Zhang,Jun-Shan Liu,Lijuan Deng,Minfeng Chen,Anita Yiu,Hui-Hui Cao,Hai-Yan Tian,Kwok-Pui Fung,Hiroshi Kurihara,Jing-Xuan Pan,Wen-Cai Ye +10 more
TL;DR: The underlying antineoplastic mechanisms of arenobufagin that involve cross talk between apoptosis and autophagy via inhibition of the PI3K/Akt/mTOR pathway are elucidated.
Journal ArticleDOI
Bufotalin from Venenum Bufonis inhibits growth of multidrug resistant HepG2 cells through G2/M cell cycle arrest and apoptosis.
Dong-Mei Zhang,Jun-Shan Liu,Ming-Kuen Tang,Anita Yiu,Hui-Hui Cao,Lei Jiang,Judy Yuet-Wa Chan,Hai-Yan Tian,Kwok-Pui Fung,Wen-Cai Ye +9 more
TL;DR: In vivo study showed that bufotalin significantly inhibited the growth of xenografted R-HepG2 cells, without body weight loss or marked toxicity towards the spleen, indicating thatbufotalin has a promising potential to become a novel anti-cancer agent for the treatment of liver cancer with multidrug resistance.
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Arenobufagin, a bufadienolide compound from toad venom, inhibits VEGF-mediated angiogenesis through suppression of VEGFR-2 signaling pathway.
Man-Mei Li,Shuai Wu,Zhong Liu,Wei Zhang,Jing Xu,Ying Wang,Jun-Shan Liu,Dong-Mei Zhang,Hai-Yan Tian,Yao-Lan Li,Wen-Cai Ye +10 more
TL;DR: It is shown that arenobufagin inhibited vascular endothelial growth factor (VEGF)-induced viability, migration, invasion and tube formation in human umbilical vein endothelial cells (HUVECs) in vitro and blocked angiogenesis in an ex vivo model.
Journal ArticleDOI
Discovery of Bufadienolides as a Novel Class of ClC-3 Chloride Channel Activators with Antitumor Activities
Jun-Shan Liu,Dong-Mei Zhang,Yuan Li,Wei-Min Chen,Zhixiong Ruan,Lijuan Deng,Liwei Wang,Hai-Yan Tian,Anita Yiu,Chun-Lin Fan,Hai Luo,Shanwen Liu,Ying Wang,Gaokeng Xiao,Lixin Chen,Wen-Cai Ye +15 more
TL;DR: It was discovered that activation of the ClC-3 Cl(-) channel, which subsequently induced inhibition of the PI3K/Akt/mTOR signaling pathway, was involved in the antitumor activities of bufadienolides.