Anita Yiu

TL;DR: The underlying antineoplastic mechanisms of arenobufagin that involve cross talk between apoptosis and autophagy via inhibition of the PI3K/Akt/mTOR pathway are elucidated.

TL;DR: In vivo study showed that bufotalin significantly inhibited the growth of xenografted R-HepG2 cells, without body weight loss or marked toxicity towards the spleen, indicating thatbufotalin has a promising potential to become a novel anti-cancer agent for the treatment of liver cancer with multidrug resistance.

TL;DR: Saxifragifolin D inhibits breast cancer cell growth and induces interplay between apoptosis and autophagy through ROS-mediated endoplasmic reticulum stress.

TL;DR: It was discovered that activation of the ClC-3 Cl(-) channel, which subsequently induced inhibition of the PI3K/Akt/mTOR signaling pathway, was involved in the antitumor activities of bufadienolides.

TL;DR: This study is the first to report the efficacy of hellebrigenin against HepG2 and elucidated its molecular mechanisms including DNA damage, mitochondria collapse, cell cycle arrest and apoptosis, which will contribute to the development of Hellebrigin into a chemotherapeutic agent in the treatment of liver cancer.