H
Hajime Ishinaga
Researcher at Mie University
Publications - 90
Citations - 1147
Hajime Ishinaga is an academic researcher from Mie University. The author has contributed to research in topics: Mucin & Cancer. The author has an hindex of 17, co-authored 82 publications receiving 1023 citations. Previous affiliations of Hajime Ishinaga include Shiga University of Medical Science & University of Rochester.
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Journal ArticleDOI
Tumor suppressor CYLD regulates acute lung injury in lethal Streptococcus pneumoniae infections
Jae Hyang Lim,Brigid Stirling,Jonathan M.J. Derry,Tomoaki Koga,Hirofumi Jono,Chang Hoon Woo,Haodong Xu,Patricia A. Bourne,Unhwan Ha,Hajime Ishinaga,Haidong Xu,Ali Andalibi,Xin-Hua Feng,Hongguang Zhu,Yuxian Huang,Yuxian Huang,Wenhong Zhang,Xinhua Weng,Chen Yan,Zhinan Yin,David E. Briles,Roger J. Davis,Richard A. Flavell,Jian Dong Li +23 more
TL;DR: CYLD was highly induced by PLY, and it inhibited MKK3-p38 kinase-dependent expression of plasminogen activator inhibitor-1 (PAI-1) in lung, thereby potentiating ALI and mortality, indicating a mechanism underlying the high early mortality of pneumococcal pneumonia.
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Long-term outcome of benign paroxysmal positional vertigo
TL;DR: To clarify long-term outcome of benign paroxysmal positional vertigo, 50 patients were followed up for a mean of 52 months and overall recurrence rate by Kaplan–Meier estimation was 37% at 60 months.
Journal ArticleDOI
TGF‐β induces p65 acetylation to enhance bacteria‐induced NF‐κB activation
Hajime Ishinaga,Hirofumi Jono,Jae Hyang Lim,Soo-Mi Kweon,Haodong Xu,Unhwan Ha,Haidong Xu,Tomoaki Koga,Chen Yan,Xin-Hua Feng,Lin Feng Chen,Jian Dong Li +11 more
TL;DR: It is shown that TGF‐β1 induces acetylation of NF‐κB p65 subunit to synergistically enhance bacterium nontypeable Haemophilus influenzae‐induced NF‐βB activation and inflammatory response in vitro and in vivo.
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Tumor suppressor CYLD acts as a negative regulator for non-typeable Haemophilus influenza-induced inflammation in the middle ear and lung of mice.
Jae Hyang Lim,Hirofumi Jono,Tomoaki Koga,Chang Hoon Woo,Hajime Ishinaga,Patricia A. Bourne,Haodong Xu,Unhwan Ha,Haidong Xu,Jian Dong Li +9 more
TL;DR: The data indicate that CYLD acts as a negative regulator for NF-κB-dependent inflammation in vivo, hence protecting the host against detrimental inflammatory response to NTHi infection.
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Pathogenesis of eosinophilic chronic rhinosinusitis.
TL;DR: This review describes the clinical course, diagnosis, and treatment of ECRS as well as its pathophysiology and the role of eosinophils, mucus, cytokines, and other mediators in the pathogenesis ofECRS.