H
Hajime Kubo
Researcher at Kyoto University
Publications - 47
Citations - 5538
Hajime Kubo is an academic researcher from Kyoto University. The author has contributed to research in topics: Lymphatic system & Vascular endothelial growth factor C. The author has an hindex of 29, co-authored 40 publications receiving 5282 citations. Previous affiliations of Hajime Kubo include University of Helsinki & Helsinki University Central Hospital.
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Journal ArticleDOI
VEGF-D promotes the metastatic spread of tumor cells via the lymphatics.
Steven A. Stacker,Carol Caesar,Megan E. Baldwin,Gillian E. Thornton,Richard A. Williams,Remko Prevo,David A. Jackson,Shin-Ichi Nishikawa,Hajime Kubo,Hajime Kubo,Marc G. Achen +10 more
TL;DR: It is demonstrated that lymphatics can be established in solid tumors and implicates VEGF family members in determining the route of metastatic spread and could be blocked with an antibody specific for V EGF-D.
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Inhibition of lymphangiogenesis with resulting lymphedema in transgenic mice expressing soluble VEGF receptor-3.
Taija Makinen,Lotta Jussila,Tanja Veikkola,Terhi Karpanen,Mikko I. Kettunen,Kalevi J. Pulkkanen,Risto A. Kauppinen,David A. Jackson,Hajime Kubo,Shin-Ichi Nishikawa,Seppo Ylä-Herttuala,Kari Alitalo +11 more
TL;DR: It is shown that a soluble form of VEGFR-3 is a potent inhibitor of Vascular endothelial growth factor (VEGF)-C and VEGF-D signaling, and when expressed in the skin of transgenic mice, it inhibits fetal lymphangiogenesis and induces a regression of already formed lymphatic vessels, though the blood vasculature remains normal.
Journal Article
Vascular Endothelial Growth Factor C Promotes Tumor Lymphangiogenesis and Intralymphatic Tumor Growth
Terhi Karpanen,Mikala Egeblad,Marika J. Karkkainen,Hajime Kubo,Seppo Ylä-Herttuala,Marja Jäättelä,Kari Alitalo +6 more
TL;DR: It is suggested that VEGF-C facilitates tumor metastasis via the lymphatic vessels and that tumor spread can be inhibited by blocking the interaction between VEGf-C and its receptor.
Journal ArticleDOI
Vascular endothelial growth factor D is dispensable for development of the lymphatic system.
Megan E. Baldwin,Michael M. Halford,Sally Roufail,Richard A. Williams,Margaret L. Hibbs,Dianne Grail,Hajime Kubo,Steven A. Stacker,Marc G. Achen +8 more
TL;DR: The lack of a profound lymphatic phenotype in Veg f-d-deficient mice suggests that Vegf-d does not play a major role in lymphatic development or that VegF-c or another, as-yet-unknown activating Vegfr-3 ligand can compensate for Vegd-d during development.
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Comparative Evaluation of FGF-2-, VEGF-A-, and VEGF-C-Induced Angiogenesis, Lymphangiogenesis, Vascular Fenestrations, and Permeability
TL;DR: Results show that VEGF-A stimulated formation of disorganized, nascent vasculatures as a result of fusion of blood capillaries into premature plexuses with only a few lymphatic vessels, highlighting the structural and functional differences between blood and lymphatic Vessels induced by FGF-2, VEGf-A, and V EGF-C.