T
Terhi Karpanen
Researcher at Ludwig Institute for Cancer Research
Publications - 47
Citations - 9405
Terhi Karpanen is an academic researcher from Ludwig Institute for Cancer Research. The author has contributed to research in topics: Lymphatic system & Vascular endothelial growth factor. The author has an hindex of 33, co-authored 47 publications receiving 8899 citations. Previous affiliations of Terhi Karpanen include University of Helsinki & Helsinki University Central Hospital.
Papers
More filters
Journal ArticleDOI
Isolated lymphatic endothelial cells transduce growth, survival and migratory signals via the VEGF‐C/D receptor VEGFR‐3
Taija Makinen,Tanja Veikkola,Satu Mustjoki,Terhi Karpanen,Bruno Catimel,Edouard C. Nice,Lyn M. Wise,Andrew A. Mercer,Heinrich Kowalski,Dontscho Kerjaschki,Steven A. Stacker,Marc G. Achen,Kari Alitalo +12 more
TL;DR: It is shown that VEGFR‐3 stimulation alone protects the lymphatic endothelial cells from serum deprivation‐induced apoptosis and induces their growth and migration, and defines the critical role of VEGF‐C/VEG FR‐3 signalling in the growth and survival of lymphatichelial cells.
Journal ArticleDOI
Inhibition of lymphangiogenesis with resulting lymphedema in transgenic mice expressing soluble VEGF receptor-3.
Taija Makinen,Lotta Jussila,Tanja Veikkola,Terhi Karpanen,Mikko I. Kettunen,Kalevi J. Pulkkanen,Risto A. Kauppinen,David A. Jackson,Hajime Kubo,Shin-Ichi Nishikawa,Seppo Ylä-Herttuala,Kari Alitalo +11 more
TL;DR: It is shown that a soluble form of VEGFR-3 is a potent inhibitor of Vascular endothelial growth factor (VEGF)-C and VEGF-D signaling, and when expressed in the skin of transgenic mice, it inhibits fetal lymphangiogenesis and induces a regression of already formed lymphatic vessels, though the blood vasculature remains normal.
Journal Article
Vascular Endothelial Growth Factor C Promotes Tumor Lymphangiogenesis and Intralymphatic Tumor Growth
Terhi Karpanen,Mikala Egeblad,Marika J. Karkkainen,Hajime Kubo,Seppo Ylä-Herttuala,Marja Jäättelä,Kari Alitalo +6 more
TL;DR: It is suggested that VEGF-C facilitates tumor metastasis via the lymphatic vessels and that tumor spread can be inhibited by blocking the interaction between VEGf-C and its receptor.
Journal ArticleDOI
Signalling via vascular endothelial growth factor receptor‐3 is sufficient for lymphangiogenesis in transgenic mice
Tanja Veikkola,Lotta Jussila,Taija Makinen,Terhi Karpanen,Michael Jeltsch,Tatiana V. Petrova,Hajime Kubo,Gavin Thurston,Donald M. McDonald,Marc G. Achen,Steven A. Stacker,Kari Alitalo +11 more
TL;DR: It is demonstrated that stimulation of the VEGFR‐3 signal transduction pathway is sufficient to induce specifically lymphangiogenesis in vivo.
Journal ArticleDOI
Vascular Endothelial Growth Factor Ligands and Receptors That Regulate Human Cytotrophoblast Survival Are Dysregulated in Severe Preeclampsia and Hemolysis, Elevated Liver Enzymes, and Low Platelets Syndrome
Yan Zhou,Michael T. McMaster,Kirstin Woo,Mary Janatpour,Jean Perry,Terhi Karpanen,Kari Alitalo,Caroline H. Damsky,Susan J. Fisher +8 more
TL;DR: VEGF family members regulate cytotrophoblast survival and that expression of a subset of family members is dysregulated in severe forms of preeclampsia, which is shown to be key regulators of conventional vasculogenesis and angiogenesis.