H
Hak Soo Choi
Researcher at Harvard University
Publications - 220
Citations - 15460
Hak Soo Choi is an academic researcher from Harvard University. The author has contributed to research in topics: Medicine & Fluorophore. The author has an hindex of 51, co-authored 194 publications receiving 12994 citations. Previous affiliations of Hak Soo Choi include Korea University & Japan Advanced Institute of Science and Technology.
Papers
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Journal ArticleDOI
Renal clearance of quantum dots.
Hak Soo Choi,Wenhao Liu,Preeti Misra,Eiichi Tanaka,John P. Zimmer,Binil Itty Ipe,Moungi G. Bawendi,John V. Frangioni,John V. Frangioni +8 more
TL;DR: This study has precisely defined the requirements for renal filtration and urinary excretion of inorganic, metal-containing nanoparticles and provides a foundation for the design and development of biologically targeted nanoparticles for biomedical applications.
Journal ArticleDOI
Design considerations for tumour-targeted nanoparticles
Hak Soo Choi,Wenhao Liu,Fangbing Liu,Khaled Nasr,Preeti Misra,Moungi G. Bawendi,John V. Frangioni +6 more
TL;DR: This study shows that quantum dots functionalized with high-affinity small-molecule ligands that target tumours can also be cleared by the kidneys if their hydrodynamic diameter is less than this value, which sets an upper limit of 5-10 ligands per quantum dot for renal clearance.
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Rapid translocation of nanoparticles from the lung airspaces to the body
Hak Soo Choi,Yoshitomo Ashitate,Jeong Heon Lee,Soon Hee Kim,Aya Matsui,Numpon Insin,Moungi G. Bawendi,Manuela Semmler-Behnke,John V. Frangioni,Akira Tsuda +9 more
TL;DR: It is demonstrated that nanoparticles with hydrodynamic diameter less than ≈34 nm and a noncationic surface charge translocate rapidly from the lung to mediastinal lymph nodes and the bloodstream, and then be subsequently cleared by the kidneys.
Journal ArticleDOI
Image-Guided Surgery Using Invisible Near-Infrared Light: Fundamentals of Clinical Translation:
TL;DR: The principles of NIR fluorescence imaging are introduced, existing NIRfluorescence imaging systems are analyzed, and the key parameters that guide contrast agent development are discussed.
Journal ArticleDOI
Targeted zwitterionic near-infrared fluorophores for improved optical imaging
Hak Soo Choi,Summer L. Gibbs,Jeong Heon Lee,Soon Hee Kim,Soon Hee Kim,Yoshitomo Ashitate,Fangbing Liu,Hoon Hyun,Gwang Li Park,Yang Xie,Soochan Bae,Maged Henary,John V. Frangioni +12 more
TL;DR: This fluorophore provides a much-improved SBR when targeted to cancer cells or proteins by conjugation with a cyclic RGD peptide, fibrinogen or antibodies, and suggests that introducing zwitterionic properties into targeted fluorophores may be a general strategy for improving the SBR in diagnostic and therapeutic applications.