H
Hakon Leffler
Researcher at Lund University
Publications - 296
Citations - 22579
Hakon Leffler is an academic researcher from Lund University. The author has contributed to research in topics: Galectin & Receptor. The author has an hindex of 80, co-authored 281 publications receiving 20756 citations. Previous affiliations of Hakon Leffler include University of Waterloo & University of Edinburgh.
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TD139, A Novel Inhaled Galectin-3 Inhibitor for The Treatment of Idiopathic Pulmonary Fibrosis (IPF). Results from The First in (IPF) Patients Study.
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Non-antibiotic prevention of urinary tract infection
TL;DR: In this article, the authors used oligosaccharides from the globoseries of glycolipids containing Gal alpha 1----4Gal to prevent adhesion and delay or decrease of infection.
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The β-galactoside binding immunomodulatory lectin galectin-3 reverses the desensitized state induced in neutrophils by the chemotactic peptide f-Met-Leu-Phe: role of reactive oxygen species generated by the NADPH-oxidase and inactivation of the agonist
Huamei Forsman,Emma Salomonsson,Karin Önnheim,Jennie Karlsson,Åse Björstad,Hakon Leffler,Johan Bylund,Anna Karlsson,Claes Dahlgren +8 more
TL;DR: It is shown that the desensitized state of neutrophils interacting with the chemotactic peptide fMLF is broken by galectin-3 and that this is achieved through an oxygen radical-mediated inactivation of the chemoattractant.
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Different fractions of human serum glycoproteins bind galectin-1 or galectin-8, and their ratio may provide a refined biomarker for pathophysiological conditions in cancer and inflammatory disease.
Michael C. Carlsson,Crina I. A. Balog,Ola Kilsgård,Thomas Hellmark,Omran Bakoush,Mårten Segelmark,Mårten Segelmark,Mårten Fernö,Håkan Olsson,Johan Malmström,Manfred Wuhrer,Hakon Leffler +11 more
TL;DR: The ratio of galECTin-1 bound/galectin-8N bound glycoproteins showed high discriminatory power between cancer patients and healthy, with AUC of 0.98 in ROC analysis, and thus provides an interesting novel cancer biomarker candidate.
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Recent progress in the understanding of the role of bacterial adhesion in the pathogenesis of urinary tract infection
TL;DR: The biochemical characterization of the bacterial ligands and epithelial cell receptors important for the attachment of most pyelonephritogenic E. coli provides a more sophisticated means of evaluating the role of bacterial adhesion in urinary tract infection.