H
Hakon Leffler
Researcher at Lund University
Publications - 296
Citations - 22579
Hakon Leffler is an academic researcher from Lund University. The author has contributed to research in topics: Galectin & Receptor. The author has an hindex of 80, co-authored 281 publications receiving 20756 citations. Previous affiliations of Hakon Leffler include University of Waterloo & University of Edinburgh.
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Characterization of the Forssman Glycolipid Hapten of Horse Kidney by Mass Spectrometry
TL;DR: The Forssman glycolipid hapten was isolated from horse kidney and analyzed by direct inlet mass spectrometry of undergraded lipid derivatives, and it was possible to conclude that the glycolIPid was a pentaglycosyl-ceramide with the sequence hexosamine-hexosamines-hexose- hexose- Hexose-hexoses-ceramides.
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Isolation and partial characterization of blood group A and H active glycosphingolipids of rat small intestine.
TL;DR: Blood group A and H active glycosphingolipids have been isolated from rat small intestine by mass spectrometry of permethylated and LiAlH4-reduced permethylation glycolipid derivatives and were shown to contain four, six, and 12 sugar residues, respectively.
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Investigation into the Feasibility of Thioditaloside as a Novel Scaffold for Galectin‐3‐Specific Inhibitors
Khuchtumur Bum-Erdene,Ivan A. Gagarinov,P.M. Collins,Moritz Winger,Andrew G. Pearson,Jennifer C. Wilson,Hakon Leffler,Ulf J. Nilsson,I. Darren Grice,Helen Blanchard +9 more
TL;DR: The synthesis of thioditaloside (TDT) and crystal structures of the galectin‐3 carbohydrate recognition domain in complexes with TDT and TDG are reported, and the different abilities of galactose and talose to anchor to the protein correlate with molecular dynamics studies, likely explaining the relative disaccharide binding affinities.
Journal Article
Glycosphingolipids of human urinary tract epithelial cells as possible receptors for adhering Escherichia coli bacteria.
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Protein subtype-targeting through ligand epimerization: talose-selectivity of galectin-4 and galectin-8.
TL;DR: A series of O2 and O3-derivatized methyl beta-d-talopyranosides were synthesized and evaluated in vitro as inhibitors of the galactose-binding galectin-1, -2, -3, -4 (N- and C-terminal domains), 8, 8N, and 9.