H
Hakon Leffler
Researcher at Lund University
Publications - 296
Citations - 22579
Hakon Leffler is an academic researcher from Lund University. The author has contributed to research in topics: Galectin & Receptor. The author has an hindex of 80, co-authored 281 publications receiving 20756 citations. Previous affiliations of Hakon Leffler include University of Waterloo & University of Edinburgh.
Papers
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Journal ArticleDOI
Pathological Lymphangiogenesis Is Regulated by Galectin-8-Dependent Crosstalk among VEGF-C, Podoplanin and Integrin Pathways
Influence ofAdhesins ontheInteraction ofEscherichia coli with HumanPhagocytes
C. Svanborg Eden,Lars Magnus Bjursten,Richard A. Hull,Sheila I. Hull,K E Magnusson,Z. Moldovano,Hakon Leffler +6 more
Patent
Galactoside inhibitors for the treatment of alpha-synucleinopthies
TL;DR: In this article, a pharmaceutical composition for use in a method for treatment or prevention of a-synucleinopathies wherein the composition comprises a molecule for pharmacological modulation of galectin activity in a mammalian brain.
Journal ArticleDOI
Synthesis and Biological Studies of O3-Aryl Galactosides as Galectin Inhibitors
Gabriella Kervefors,Kumar Bhaskar Pal,Gergely L. Tolnai,Gergely L. Tolnai,Mukul Mahanti,Hakon Leffler,Ulf J. Nilsson,Berit Olofsson +7 more
TL;DR: In this article, a library of O3-arylated galactosides with varying substitution patterns was designed to study such inhibitions further, and a selection of derivatives were evaluated for inhibitory potencies against galectins-1, 3, 4 N, 4 C (C-terminal domain), 7, 8 N, 8 C, 9 N, and 9 C and one compound with promising affinity and selectivity for both the N- and Cterminal domains of galectin-9 was discovered.
Journal ArticleDOI
Evaluating the affinity and kinetics of small molecule glycomimetics for human and mouse galectin-3 using surface plasmon resonance.
Henry Ong Wah Kim,Céline Ronin,James A. Roper,Barbro Kahl-Knutson,Kristoffer Peterson,Hakon Leffler,Ulf J. Nilsson,Anders Pedersen,Fredrik Zetterberg,Robert J. Slack +9 more
TL;DR: In this article , the authors compare human and mouse galectin-3 affinity measures between FP and SPR, as well as investigate compound kinetics, and find that FP is a viable alternative to SPR for early drug discovery screening and determining KD values.