H
Hakon Leffler
Researcher at Lund University
Publications - 296
Citations - 22579
Hakon Leffler is an academic researcher from Lund University. The author has contributed to research in topics: Galectin & Receptor. The author has an hindex of 80, co-authored 281 publications receiving 20756 citations. Previous affiliations of Hakon Leffler include University of Waterloo & University of Edinburgh.
Papers
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Journal ArticleDOI
Novel Selective Galectin-3 Antagonists Are Cytotoxic to Acute Lymphoblastic Leukemia.
Khuchtumur Bum-Erdene,P.M. Collins,Matthew W. Hugo,Somayeh S. Tarighat,Fei Fei,Chandan Kishor,Hakon Leffler,Ulf J. Nilsson,John Groffen,Darren Grice,Nora Heisterkamp,Helen Blanchard +11 more
TL;DR: These compounds are promising leads for therapeutics, targeting the tumor-supportive activities of galectin-3 in cancer, and decreased the viability of ALL cells even when grown in the presence of protective stromal cells.
Journal Article
The role of epithelial cell surface glycoconjugates in self-not-self and self-self interaction.
Journal ArticleDOI
Selective Monovalent Galectin-8 Ligands Based on 3-Lactoylgalactoside.
Benedetta Girardi,Benedetta Girardi,Martina Manna,Sjors Van Klaveren,Sjors Van Klaveren,Tihomir Tomašič,Žiga Jakopin,Hakon Leffler,Ulf J. Nilsson,Daniel Ricklin,Janez Mravljak,Oliver Schwardt,Marko Anderluh +12 more
TL;DR: In this article, the authors improved the affinity and target selectivity of a recently published Galectin-8 ligand, 3-O-[1-carboxyethyl]-β-d-galactopyranoside, by introducing modifications at positions 1 and 3 of the galactose.
Book ChapterDOI
Strategies for studying bacterial adhesion in Vivo
TL;DR: This chapter provides an example of studies at each level of studies on microbial adhesion and discusses the implications for what might occur in vivo.