H
Hakon Leffler
Researcher at Lund University
Publications - 296
Citations - 22579
Hakon Leffler is an academic researcher from Lund University. The author has contributed to research in topics: Galectin & Receptor. The author has an hindex of 80, co-authored 281 publications receiving 20756 citations. Previous affiliations of Hakon Leffler include University of Waterloo & University of Edinburgh.
Papers
More filters
Journal ArticleDOI
Glycoproteomic identification of galectin-3 and -8 ligands in bronchoalveolar lavage of mild asthmatics and healthy subjects ☆
Cecilia Cederfur,Johan Malmström,Kristian Nihlberg,Mattias Block,Michael E. Breimer,Leif Bjermer,Gunilla Westergren-Thorsson,Hakon Leffler +7 more
TL;DR: The low relative concentration of galectins in BAL makes it likely that functional interactions with glycoproteins occur at sites rich in galectin, such as cells of the airways, rather than the extracellular fluid itself.
Journal ArticleDOI
Ligand binding and complex formation of galectin-3 is modulated by pH variations.
TL;DR: The results of the present study suggest that the formation and composition of galectin-3 networks can be fine-tuned by changes in the environmental pH.
Journal ArticleDOI
Fecal excretion of intestinal glycosphingolipids by newborns and young children
TL;DR: From the time of weaning lactosylceramide abruptly became and then persisted as a dominating glycolipid although cerebroside, complex gangliosides and blood group active fucolipids could still be detected in feces even at 2 years of age.
Journal ArticleDOI
Quinoline-galactose hybrids bind selectively with high affinity to a galectin-8 N-terminal domain.
Kumar Bhaskar Pal,Mukul Mahanti,Xiaoli Huang,Stella Persson,Anders Sundin,Fredrik Zetterberg,Stina Oredsson,Hakon Leffler,Ulf J. Nilsson +8 more
TL;DR: Improved affinity, selectivity, and low cytotoxicity suggest that the quinoline-galactoside derivatives provide an attractive starting point for the development of galectin-8N inhibitors potentially interfering with pathological lymphangiogenesis, autophagy, and tumor progression.
Journal ArticleDOI
Structural characterization of glycolipids of rat small intestine having one to eight hexoses in a linear sequence
Jonas Ångström,Michael E. Breimer,Karl-Erik Falk,Gunnar C. Hansson,Karl-Andres Karlsson,Hakon Leffler,Irmin Pascher +6 more
TL;DR: Glycolipid studies of isolated mucosal epithelial cells and the nonepithelial intestinal residue revealed a specific cell distribution of these hexosyl compounds.