H
Hamid Mostafavi Abdolmaleky
Researcher at Boston University
Publications - 47
Citations - 3478
Hamid Mostafavi Abdolmaleky is an academic researcher from Boston University. The author has contributed to research in topics: DNA methylation & Epigenetics. The author has an hindex of 26, co-authored 45 publications receiving 3162 citations. Previous affiliations of Hamid Mostafavi Abdolmaleky include Tehran University of Medical Sciences & Beth Israel Deaconess Medical Center.
Papers
More filters
Journal ArticleDOI
Hypomethylation of MB-COMT promoter is a major risk factor for schizophrenia and bipolar disorder
Hamid Mostafavi Abdolmaleky,Kuang-hung Cheng,Stephen V. Faraone,Marsha A. Wilcox,Stephen J. Glatt,Fangming Gao,Cassandra L. Smith,Rahim Shafa,Batol Aeali,Julie Carnevale,Hongjie Pan,Panagiotis Papageorgis,Jose F. Ponte,Vadivelu Sivaraman,Ming T. Tsuang,Ming T. Tsuang,Sam Thiagalingam +16 more
TL;DR: It is suggested that MB-COMT over-expression due to promoter hypomethylation and/or hyperactive allele of COMT may increase dopamine degradation in the frontal lobe providing a molecular basis for the shared symptoms of schizophrenia and bipolar disorder.
Journal ArticleDOI
Hypermethylation of the reelin (RELN) promoter in the brain of schizophrenic patients: a preliminary report.
Hamid Mostafavi Abdolmaleky,Kuang-hung Cheng,Andrea L. Russo,Cassandra L. Smith,Stephen V. Faraone,Marsha A. Wilcox,Rahim Shafa,Stephen J. Glatt,Giang H. Nguyen,Joe F. Ponte,Sam Thiagalingam,Ming T. Tsuang +11 more
TL;DR: Promoter hypermethylation of the RELN gene could be a significant contributor in effecting epigenetic alterations and provides a molecular basis for the RELn gene hypoactivity in schizophrenia, according to the small sample size.
Journal ArticleDOI
Methylomics in psychiatry: Modulation of gene-environment interactions may be through DNA methylation.
Hamid Mostafavi Abdolmaleky,Cassandra L. Smith,Stephen V. Faraone,Stephen V. Faraone,Rahim Shafa,William S. Stone,William S. Stone,Stephen J. Glatt,Stephen J. Glatt,Ming T. Tsuang +9 more
TL;DR: DNA methylation usually increases with age, although hypomethylation of the promoter region of the amyloid A4 precursor gene during aging may play a role in Alzheimer's disease.
Journal ArticleDOI
Meta-analysis of association between the T102C polymorphism of the 5HT2a receptor gene and schizophrenia.
Hamid Mostafavi Abdolmaleky,Hamid Mostafavi Abdolmaleky,Hamid Mostafavi Abdolmaleky,Stephen V. Faraone,Stephen V. Faraone,Stephen J. Glatt,Stephen J. Glatt,Ming T. Tsuang +7 more
TL;DR: A meta-analysis of whole-genome linkage scans confirmed linkage between schizophrenia and markers on the long arm of chromosome 13 and found a significant association between the C allele of the T102C polymorphism and schizophrenia, which was more pronounced in European samples than in the entire sample.
Journal ArticleDOI
Epigenetic dysregulation of HTR2A in the brain of patients with schizophrenia and bipolar disorder.
Hamid Mostafavi Abdolmaleky,Hamid Mostafavi Abdolmaleky,Sahab Yaqubi,Sahab Yaqubi,Panagiotis Papageorgis,Arthur W. Lambert,Sait Ozturk,Vadivelu Sivaraman,Sam Thiagalingam +8 more
TL;DR: Epigenetic dysregulation of HTR2A may contribute to SCZ, BD and earlier age of disease onset and further research is required to delineate the Dysregulation of other components of serotoninergic pathway to design new therapeutics based on the downstream effects of serotonin.