William S. Stone

TL;DR: In this article , a two-stage genome-wide association study of up to 76,755 individuals with schizophrenia and 243,649 control individuals was conducted, and the authors reported common variant associations at 287 distinct genomic loci.

TL;DR: This is the first large-scale, multisite, family-based heritability study of a collection of endophenotypic measures for schizophrenia and suggests that endophenotypes are important measures to consider in characterizing the genetic basis of schizophrenia.

TL;DR: The Consortium on the Genetics of Schizophrenia (COGS) as mentioned in this paper examined the genetic architecture of quantitative endophenotypes in families with schizophrenia, including attention, verbal memory, working memory, and a computerized neurocognitive battery.

TL;DR: Schizotaxia provides a useful way to conceptualise both the liability for schizophrenia, and also the development of treatment strategies aimed at the eventual prevention of the illness.

TL;DR: The duration of bouts of paradoxical sleep was strongly correlated with several cognitive measures and selected serotonergic markers, which suggests that changes in sleep patterns and brain biochemistry contribute directly to deficits in learning and memory, or that the same neurobiological defect contributes to age-related impairments in sleep and in memory.